Description

p-Nitrophenylacetic Acid (CAS No. 104-03-0) is a high-purity organic compound with the molecular formula C₈H₇NO₄, widely utilized in pharmaceutical, biochemical, and synthetic chemistry research. This yellow crystalline solid, also known as 2-(4-nitrophenyl)acetic acid, exhibits excellent solubility in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), making it ideal for laboratory applications. With a molecular weight of 181.15 g/mol, it serves as a versatile intermediate for synthesizing dyes, agrochemicals, and active pharmaceutical ingredients (APIs). Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in secure, moisture-resistant packaging to maintain stability. Suitable for use in coupling reactions, enzyme assays, and as a precursor for nitrophenyl derivatives, this compound is a must-have for researchers seeking reliable and high-quality reagents.

Properties

• CAS Number: 104-03-0
• Complexity: 203
• IUPAC Name: 2-(4-nitrophenyl)acetic acid
• InChI: InChI=1S/C8H7NO4/c10-8(11)5-6-1-3-7(4-2-6)9(12)13/h1-4H,5H2,(H,10,11)
• InChI Key: YBADLXQNJCMBKR-UHFFFAOYSA-N
• Exact Mass: 181.03750770
• Molecular Formula: C8H7NO4
• Molecular Weight: 181.15
• SMILES: C1=CC(=CC=C1CC(=O)O)[N+](=O)[O-]
• Topological: 83.1
• Monoisotopic Mass: 181.03750770
• Physical Description: Pale yellow solid; Yellow powder;
• Vapor Pressure: 0.0000291 [mmHg]
• Synonyms: 4-Nitrophenylacetic acid, 104-03-0, p-nitrophenylacetic acid, (4-Nitrophenyl)acetic acid, 4-Nitrobenzeneacetic acid, Benzeneacetic acid, 4-nitro-, 2-(p-Nitrophenyl)acetic acid, Acetic acid, (p-nitrophenyl)-, (p-Nitrophenyl)acetic acid, CCRIS 2338, NSC 5398, EINECS 203-168-5, KLB4P626RE, AI3-15093, NSC-5398, DTXSID6059289, CHEBI:40443, P-NITRO-.ALPHA.-TOLUIC ACID, 4-NITROPHENYLACETIC ACID [MI], p-nitro-alpha-toluic acid, 4nitrophenylacetic acid, 4Nitrobenzeneacetic acid, (pNitrophenyl)acetic acid, (4Nitrophenyl)acetic acid, 2(pNitrophenyl)acetic acid, Benzeneacetic acid, 4nitro, Acetic acid, (pnitrophenyl), DTXCID8032837, 203-168-5, inchi=1/c8h7no4/c10-8(11)5-6-1-3-7(4-2-6)9(12)13/h1-4h,5h2,(h,10,11, 2-(4-NITROPHENYL)ACETIC ACID, 4-nitrophenylacetate, MFCD00007383, (4-Nitro-phenyl)-acetic acid, 4-nitrophenylaceticacid, 1ajn, 4-Nitrophenylaetic acid, 4-Nitrobenzencacetic Acid, UNII-KLB4P626RE, 4-nitro-Benzeneacetic acid,, p-nitrophenyl acetic acid, 4-Nitrophenylacetate acid, 4-nitrophenyl acetic acid, (p-nitrophenyl) acetic acid, (4-nitrophenyl)-acetic acid, Oprea1_127303, SCHEMBL76204, SCHEMBL3089874, SCHEMBL13941612, SCHEMBL14691385, SCHEMBL28140775, NSC5398, BDBM237235, HMS3604G17, acetic acid, 2-(4-nitrophenyl)-, CS-D1370, STR00634, BBL012452, CCG-41548, SBB056678, STK054869, AKOS000104752, AKOS040744590, AC-2513, DB07331, FN64699, s12333, SY001731, N0227, NS00041354, ST50406181, EN300-20166, 4-Nitrophenylacetic acid, ReagentPlus(R), 99%, AE-641/02392058, SR-01000631614-1, Q27096559, 4-Nitrophenylacetic acid, Vetec(TM) reagent grade, 98%, F2191-0048, Z104477118

Application

p-Nitrophenylacetic acid is commonly employed as a key intermediate in organic synthesis, particularly in the preparation of pharmaceuticals and specialty chemicals. It serves as a precursor for chromogenic substrates in enzyme-linked immunosorbent assays (ELISA) and other biochemical assays. Researchers also utilize it in the development of nitroaromatic compounds for agrochemical and material science applications. Its reactivity makes it valuable in peptide coupling and esterification reactions.

Safety and Hazards

GHS Hazard Statements

• H315 (93.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (92.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (92.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (93.3%)
• Eye Irrit. 2 (92.2%)
• STOT SE 3 (92.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.