Description

(p-Iodophenoxy)acetic acid (CAS No. 1878-94-0) is a high-purity iodinated aromatic compound with the molecular formula C₈H₇IO₃ and IUPAC name 2-(4-iodophenoxy)acetic acid. This white to off-white crystalline powder is a versatile synthetic intermediate widely utilized in organic synthesis, pharmaceutical research, and agrochemical development. With a molecular weight of 278.05 g/mol, it exhibits excellent stability under standard laboratory conditions. Our product is rigorously analyzed by HPLC, NMR, and mass spectrometry to ensure ≥98% purity, making it ideal for precision applications. Packaged under inert gas in amber glass vials to prevent degradation, it is suitable for use as a building block in heterocyclic chemistry, ligand synthesis, and radiopharmaceutical labeling. Researchers value its reactivity in ether and carboxylic acid functional groups for cross-coupling reactions and structure-activity relationship studies.

Properties

• CAS Number: 1878-94-0
• Complexity: 152
• IUPAC Name: 2-(4-iodophenoxy)acetic acid
• InChI: InChI=1S/C8H7IO3/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2,(H,10,11)
• InChI Key: RKORKXFKXYYHAQ-UHFFFAOYSA-N
• Exact Mass: 277.94399
• Molecular Formula: C8H7IO3
• Molecular Weight: 278.04
• SMILES: C1=CC(=CC=C1OCC(=O)O)I
• Topological: 46.5
• Monoisotopic Mass: 277.94399
• Synonyms: 4-Iodophenoxyacetic acid, 1878-94-0, (p-Iodophenoxy)acetic acid, EINECS 217-531-0, DTXSID80172092, DTXCID9094583, 217-531-0, 2-(4-iodophenoxy)acetic acid, (4-iodophenoxy)acetic acid, Acetic acid, 2-(4-iodophenoxy)-, Acetic acid, (4-iodophenoxy)-, MFCD00014359, P-IODOPHENOXYACETIC ACID, (4-iodo-phenoxy)acetic acid, Oprea1_031755, Oprea1_327553, (4-Iodo-phenoxy)-acetic acid, CHEMBL366651, SCHEMBL2113374, 4-Iodophenoxyacetic acid, 95%, RKORKXFKXYYHAQ-UHFFFAOYSA-, SBB063740, STL164358, AKOS001042351, BS-5021, FI70889, AC-10148, SY049560, DB-044660, I0644, NS00026148, EN300-17493, AG-690/13155018, Z56943814, InChI=1/C8H7IO3/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2,(H,10,11)

Application

This compound serves as a key precursor in the synthesis of thyroid hormone analogs and radiopharmaceutical contrast agents due to its stable iodine moiety. In plant biology research, it functions as a synthetic auxin analog for studying growth regulators. The carboxylic acid group enables conjugation to biomolecules for targeted drug delivery systems, while the phenoxy component facilitates incorporation into liquid crystal materials and polymer modifiers.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (83.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (83.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.