Description

o-Toluidine (CAS 95-53-4) is a high-purity aromatic amine with the molecular formula C₇H₉N, widely utilized in chemical synthesis and industrial applications. This colorless to pale yellow liquid (or solid, depending on temperature) exhibits a characteristic aromatic odor and is soluble in organic solvents such as ethanol, ether, and benzene. o-Toluidine is a critical intermediate in the production of dyes, pharmaceuticals, rubber chemicals, and agrochemicals. It is also employed as a reagent in analytical chemistry for the detection of oxidizing agents. Our premium-grade o-Toluidine is rigorously tested to ensure ≥99% purity, making it ideal for research laboratories, pharmaceutical manufacturing, and specialty chemical synthesis. Proper handling is essential due to its toxicity and potential carcinogenicity—always use PPE and adhere to safety protocols.

Properties

• CAS Number: 95-53-4
• Complexity: 70.8
• IUPAC Name: 2-methylaniline
• InChI: InChI=1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3
• InChI Key: RNVCVTLRINQCPJ-UHFFFAOYSA-N
• LogP: log Kow = 1.32
• Exact Mass: 107.073499291
• Molecular Formula: C7H9N
• Molecular Weight: 107.15
• SMILES: CC1=CC=CC=C1N
• Topological: 26
• Monoisotopic Mass: 107.073499291
• Physical Description: O-toluidine appears as a clear colorless or light yellow liquid. May become reddish brown on exposure to air and light. Flash point 185 °F. Has about the same density as water and is very slightly soluble in water. Vapors are heavier than air. Confirmed carcinogen.
• Color/Form: Light yellow liquid becoming reddish brown on exposure to air and light
• Odor: Aromatic aniline-like odor
• Boiling Point: 392 to 396 °F at 760 mmHg
• Melting Point: 2.7 °F
• Flash Point: 185 °F
• Solubility: 5 to 10 mg/mL at 59 °F
• Density: 0.998 at 68 °F – Less dense than water; will float
• Vapor Density: 3.69 – Heavier than air; will sink
• Vapor Pressure: 0.1 mmHg at 68 °F ; 0.3 mmHg at 86 °F
• Henry’s Law Constant: Henry’s Law constant = 1.98X10-6 atm-cu m/mol at 25 °C
• Autoignition Temperature: 900 °F
• Viscosity: 3.823 mPa-s at 25 °C
• Heat of Combustion: -16,180 Btu/lb; -8,990 cal/g; -376×10+6 J/kg
• Heat of Vaporization: 44.6 kJ/mol at 200.3 °C
• Surface Tension: 43.55 dynes/cm; 0.04355 Newtons/meter at 20 °C
• Ionization Potential: 7.44 eV
• Odor Threshold: Odor Threshold Low: 0.02 [ppm]
• Refractive Index: Index of refraction: 1.5688 at 20 °C/D
• Dissociation Constants: pKa = 4.44 at 25 °C
• Synonyms: o-Toluidine, 2-Methylaniline, o-Tolylamine, 2-Methylbenzenamine, o-Methylaniline, ortho-toluidine, 2-Methyl-1-aminobenzene, o-Aminotoluene, o-Methylbenzenamine, 1-Amino-2-methylbenzene, 2-Amino-1-methylbenzene, o-Toluidin, o-Toluidyna, 1-Methyl-2-aminobenzene, ortho Toluidine, Aniline, 2-methyl-, 2-Methylbenzamine, RCRA waste number U328, 2-methylphenylamine, CCRIS 597, NSC 15348, DTXSID1026164, HSDB 2042, 2-tolylamine, UNII-B635MZ0ZLU, C.I. 37077, EINECS 202-429-0, B635MZ0ZLU, CHEBI:66892, AI3-24383, NSC-15348, DTXCID206164, EC 202-429-0, NSC15348, ORTHO-TOLUIDINE (IARC), ORTHO-TOLUIDINE [IARC], PRILOCAINE IMPURITY B (EP IMPURITY), PRILOCAINE IMPURITY B [EP IMPURITY], TOLUIDINE (ORTHO), CI 37077, 202-429-0, o-toluidine (acgih:osha), 95-53-4, 2-Toluidine, 2-AMINOTOLUENE, Benzenamine, 2-methyl-, 2-methyl-aniline, Benzenamine, methyl-, o-Toluidin [Czech], 2-Toluidine-d7, o-Toluidyna [Polish], o-Toluide, MFCD00007730, O-TOLUIDINE-D3 (METHYL-D3), 121536-13-8, O-Toluidin (CZECH), O-Toluidyna (POLISH), 68408-22-0, CAS-95-53-4, RCRA waste no. U328, ortho-tolylamine, o-tolyl-amine, 2-amino toluene, 2 -methylaniline, 2-methyl aniline, 2-(methyl)aniline, 51V, o-Toluidine, liquid, 2-methyl-benzenamine, o-Toluidine, 98%, o-Toluidine, >=99%, O-TOLUIDINE [MI], O-TOLUIDINE(1%), CHEMBL1381, WLN: ZR B1, SCHEMBL11863, SCHEMBL15789, SCHEMBL61229, SCHEMBL67429, SCHEMBL74259, SCHEMBL75807, o-Toluidine, liquid or solid, MLS002415766, 2-Aminotoluene (o-toluidine), BIDD:ER0679, SCHEMBL138256, SCHEMBL294766, 2-AMINOTOLUENE [HSDB], SCHEMBL1077811, SCHEMBL2155182, o-Toluidine, analytical standard, O-Toluidine (ACD/Name 4.0), o-Toluidine, p.a., 99.5%, MSK1218, 2-Methylbenzenamine (o-Toluidine), HMS3039B11, BCP17522, STR00213, Tox21_201256, Tox21_300179, SBB028141, STL163331, 2-Methylphenylamine (ACD/Name 4.0), AKOS000119109, o-Toluidine 500 microg/mL in Methanol, NCGC00091368-01, NCGC00091368-02, NCGC00091368-03, NCGC00091368-04, NCGC00253986-01, NCGC00258808-01, o-Toluidine 10 microg/mL in Cyclohexane, BP-21341, SMR001370921, o-Toluidine 100 microg/mL in Cyclohexane, NS00008265, o-Toluidine, SAJ special grade, >=99.0%, ST45255278, T0299, EN300-33459, o-Toluidine, purum p.a., >=99.5% (GC), C90102, Q311695, o-Toluidine, liquid or solid [UN1708] [Poison], Z57127943, F2190-0418, PRILOCAINE HYDROCHLORIDE IMPURITY B [EP IMPURITY], InChI=1/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H

o-Toluidine is primarily used as a precursor in the synthesis of dyes, including azo dyes for textiles and pigments. In pharmaceuticals, it serves as an intermediate for producing local anesthetics and other active compounds. Additionally, it acts as a vulcanization accelerator in rubber manufacturing and a corrosion inhibitor in industrial processes. Researchers leverage its reactivity in organic synthesis and analytical methods, such as spectrophotometric detection of nitrites.

Safety and Hazards

GHS Hazard Statements

• H227: Combustible liquid [Warning Flammable liquids]
• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332: Harmful if inhaled [Warning Acute toxicity, inhalation]
• H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
• H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]
• H350: May cause cancer [Danger Carcinogenicity]
• H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]
• H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
• H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P203, P210, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P330, P337+P317, P370+P378, P391, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Flammable liquids – Category 4
• Acute toxicity – Category 4
• Acute toxicity – Category 5
• Acute toxicity – Category 3
• Skin corrosion/irritation – Category 3
• Serious eye damage/eye irritation – Category 2A-2B
• Carcinogenicity – Category 1B
• Specific target organ toxicity – Single exposure – Category 1
• Specific target organ toxicity – Repeated exposure – Category 1
• Hazardous to the aquatic environment – Category 2
• Hazardous to the aquatic environment – Category 2

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.