Description

NSI-189 (CAS No. 1270138-40-3) is a novel, small-molecule compound with the molecular formula C₂₂H₃₀N₄O and IUPAC name (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone. This investigational neurogenic compound has garnered significant interest in neuroscience research due to its potential to stimulate hippocampal neurogenesis. NSI-189 exhibits high purity (>98%) and is supplied as a stable, lyophilized powder suitable for research applications. Its unique mechanism of action and structural properties make it a valuable tool for studying neuroplasticity, cognitive function, and mood regulation pathways. Proper storage at -20°C is recommended to maintain long-term stability.

Properties

• CAS Number: 1270138-40-3
• Complexity: 442
• IUPAC Name: (4-benzylpiperazin-1-yl)-[2-(isopentylamino)-3-pyridyl]methanone
• InChI: InChI=1S/C22H30N4O/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24)
• InChI Key: DYTOQURYRYYNOR-UHFFFAOYSA-N
• Exact Mass: 366.24196159
• Molecular Formula: C22H30N4O
• Molecular Weight: 366.5
• SMILES: CC(C)CCNC1=C(C=CC=N1)C(=O)N2CCN(CC2)CC3=CC=CC=C3
• Topological: 48.5
• Monoisotopic Mass: 366.24196159
• Synonyms: NSI-189, 1270138-40-3, (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone, YVE9U408ZL, Methanone, [2-[(3-methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]-, Methanone, (2-((3-methylbutyl)amino)-3-pyridinyl)(4-(phenylmethyl)-1-piperazinyl)-, [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone, (4-benzylpiperazin-1-yl)-(2-(3-methylbutylamino)pyridin-3-yl)methanone, (2-((3-Methylbutyl)amino)-3-pyridinyl)(4-(phenylmethyl)-1-piperazinyl)methanone, (4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone, UNII-YVE9U408ZL, (2-((3-Methylbutyl)amino)-3-pyridinyl)(4-(phenylmethyl)-1-piperazinyl)-methanone, [2-[(3-methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]-Methanone, NSI 189, MFCD26959792, SCHEMBL9999791, CHEMBL4302505, EX-A277, CHEBI:228696, BDBM655802, DTXSID901025668, HMS3886A14, BCP08748, NSI-189?, s5620, (4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone (NSI-189), AKOS025395148, CCG-268247, CS-2029, SB17520, US20240067625, Compound 29, NCGC00371142-05, AC-31950, AS-19608, DA-46482, FN138081, HY-13999, NS00098469, BRD-K74371986-001-01-7, Q15409359, (4-benzylpiperazin-1-yl)-[2-(isopentylamino)-3-pyridyl]methanone, NSI-189 ((4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone)

Application

NSI-189 is primarily utilized in preclinical research to investigate neurogenesis and neuroplasticity mechanisms. Studies suggest its potential application in models of cognitive impairment and mood disorders. Researchers employ NSI-189 to explore hippocampal-dependent learning and memory processes. The compound has shown promise in experimental models of depression and neurodegenerative conditions. Its effects on neuronal differentiation and synaptic plasticity make it valuable for neurobiological studies.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P319, P321, P330, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Acute Tox. 4 (50%)
• Acute Tox. 4 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.