Description

Notoginsenoside R1 (CAS No. 80418-24-2) is a high-purity saponin compound derived from Panax notoginseng, a traditional medicinal herb. With the molecular formula C₄₇H₈₀O₁₈, this bioactive glycoside is characterized by its complex triterpenoid structure, featuring multiple hydroxyl and glycosidic moieties. Notoginsenoside R1 is widely utilized in pharmacological research due to its anti-inflammatory, neuroprotective, and cardioprotective properties. This product is rigorously tested via HPLC (>98% purity) and is supplied as a white to off-white powder, ensuring consistency for in vitro and in vivo studies. Ideal for researchers investigating natural product chemistry, traditional medicine mechanisms, or novel therapeutic agents.

Properties

• CAS Number: 80418-24-2
• Complexity: 1670
• IUPAC Name: (2S,3R,4S,5S,6R)-2-[(1S)-1-[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-6-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxytetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,5-dimethyl-hex-4-enoxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
• InChI: InChI=1S/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39-,40-,41-,42+,44+,45+,46+,47-/m0/s1
• InChI Key: LLPWNQMSUYAGQI-OOSPGMBYSA-N
• Exact Mass: 932.53446570
• Molecular Formula: C47H80O18
• Molecular Weight: 933.1
• SMILES: CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H](CO6)O)O)O)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C
• Topological: 298
• Monoisotopic Mass: 932.53446570
• Color/Form: White to off-white powder
• Solubility: In water, 1 mg/mL, clear colorless solution
• Stability/Shelf Life: Stable under recommended storage conditions.
• Synonyms: Notoginsenoside R1, 80418-24-2, Sanchinoside R1, O-Acetylseudolaric acid C, Sanqi glucoside R1, CHEBI:77149, UNII-Z62692362Z, (20S)-ginsenoside R1, Z62692362Z, HSDB 8111, (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside, beta-D-Glucopyranoside, (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-, Notoginsenoside R 1, NOTOGINSENOSIDE R1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG), (-)-pseudolaric acid b, notoginsenoside-R1, MFCD00210535, b-D-Glucopyranoside,(3b,6a,12b)-20-(b-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-b-D-xylopyranosyl-, CHEMBL507115, Sanchinoside R1;Sanqi glucoside R1, NotoginsenosideR1, ss-D-Glucopyranoside, (3ss,6a,12ss)-20-(ss-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-ss-D-xylopyranosyl-; Dammarane, ss-D-glucopyranoside deriv.; (3ss,6a,12ss)-20-(ss-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-ss-D-xylopyranosyl-ss-D-glucopyranoside; Notoginsenoside R1; Sanchinoside R1; Sanqi glucoside R1, Notoginsenoside R1 (Standard), SCHEMBL28130814, HY-N0615R, DTXSID101036451, HY-N0615, MSK40040, s3785, AKOS025311471, CCG-270581, CS-4167, Notoginsenoside R1, >=98% (HPLC), Notoginsenoside R1, analytical standard, ON10463, 1ST40040, AC-34698, BS-17596, C08961, Q27105065, .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-20-(.BETA.-D-GLUCOPYRANOSYLOXY)-3,12-DIHYDROXYDAMMAR-24-EN-6-YL 2-O-.BETA.-D-XYLOPYRANOSYL-, NOTOGINSENOSIDE R1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC], Sanchinoside R1;(3b,6a,12b)-20-(b-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-b-D-xylopyranosyl-b-D-glucopyranoside

Application

Notoginsenoside R1 is extensively studied for its potential in cardiovascular research, particularly for its vasodilatory and anti-thrombotic effects. It has shown promise in neuroprotection, mitigating oxidative stress and apoptosis in neuronal cells. Additionally, this compound is a key marker for quality control in Panax notoginseng-based herbal formulations.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

Precautionary Statements

• P264, P270, P301+P317, P330, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)

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