Description

N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) is a high-purity silylation reagent widely used in gas chromatography (GC) derivatization for the analysis of polar compounds. With the molecular formula C₈H₁₈F₃NOSi₂ and CAS number 25561-30-2, this reagent enhances the volatility and thermal stability of analytes, improving chromatographic performance. Available in various formulations, including with 1% or 10% trimethylchlorosilane (TMCS), BSTFA is packaged under argon to ensure stability and prevent moisture contamination. Ideal for research, pharmaceutical, and environmental testing, it is compatible with a broad range of functional groups, including alcohols, amines, and carboxylic acids. Our BSTFA is rigorously tested for derivatization efficiency, ensuring reliable and reproducible results for sensitive analytical applications.

Properties

• CAS Number: 25561-30-2
• Complexity: 250
• IUPAC Name: trimethylsilyl (1E)-2,2,2-trifluoro-N-trimethylsilyl-ethanimidate
• InChI: InChI=1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+
• InChI Key: XCOBLONWWXQEBS-KPKJPENVSA-N
• Exact Mass: 257.08790175
• Molecular Formula: C8H18F3NOSi2
• Molecular Weight: 257.40
• SMILES: C[Si](C)(C)/N=C(C(F)(F)F)/O[Si](C)(C)C
• Topological: 21.6
• Monoisotopic Mass: 257.08790175
• Physical Description: Colorless liquid;
• Synonyms: N,O-Bis(trimethylsilyl)trifluoroacetamide, 25561-30-2, N,O-BSTFA, CHEBI:85067, Trimethylsilyl 2,2,2-trifluoro-N-(trimethylsilyl)ethanimidate, DTXSID001015789, N,O-bis(TMS)3FAN, BSTFA, Derivatization Grade, DTXCID401473949, Trimethylsilyl 2,2,2trifluoroN(trimethylsilyl)acetimidate, un2924, BSTFA + TMCS, MFCD00008269, N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane, trimethylsilyl (1E)-2,2,2-trifluoro-N-trimethylsilylethanimidate, trimethylsilyl (1Z)-2,2,2-trifluoro-N-trimethylsilylethanimidate, BSTFA (with 1% TMCS), Trimethylsilyl (E)-2,2,2-trifluoro-N-(trimethylsilyl)acetimidate, NSC379423, s5443, AKOS005063571, CCG-267034, NSC-379423, N,0-bis(trimethylsilyl)trifluoroacetamide, BS-16786, HY-123798, CS-0085821, No-Bis(Trimethylsilyl)Trifluoroacetamide 99%, S02825, N,O-Bis(Trimethylsilyl)Trifluoroacetamide, 98%, Bis(trimethylsilyl)trifluoroacetamide with 1% TMCS, N,O-Bis(trimethylsilyl)trifluoroacetamide, >=99%, N,O-Bis(trimethylsilyl)trifluoroacetamide with 10% TMCS, N,O-Bis(Trimethylsilyl)Trifluoroacetamide, With 1% Tmcs, N,O-Bis(Trimethylsilyl)Trifluoroacetamide, 98%, J&Kseal, Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane, N,O-Bis(Trimethylsilyl)Trifluoroacetamide, Contains 10% Tmcs, BSTFA (with 1% TMCS), kit of 10 x 1 mL, analytical standard, N,O-Bis(trimethylsilyl)trifluoroacetamide, for GC derivatization, >=99.0%, N,O-Bis(Trimethylsilyl)Trifluoroacetamide, Contains 1% Tmcs, Ampuled Under Argon, N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, ampouled under argon, N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane, for GC derivatization, contains 1% TMCS, 99% (excluding TMCS), N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane, for GC derivatization, contains 10% TMCS, 98% (excluding TMCS), N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane, with 1% trimethylchlorosilane, for GC derivatization, N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane, with 1% trimethylchlorosilane, for GC derivatization, >=99.0%, N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane, with 10% trimethylchlorosilane, for GC derivatization, >=98.0%, N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, packaged under Argon in resealable ChemSeal bottles

BSTFA is primarily used as a derivatizing agent in gas chromatography to convert polar compounds into volatile, thermally stable trimethylsilyl (TMS) derivatives. It is essential for analyzing metabolites, steroids, and environmental contaminants by GC-MS. The addition of TMCS (1% or 10%) catalyzes silylation reactions, improving reaction rates and completeness. Suitable for pharmaceutical, forensic, and environmental laboratories, BSTFA ensures accurate quantification and identification of challenging analytes.

Safety and Hazards

GHS Hazard Statements

• H225 (56.7%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H226 (43.3%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (19.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (76.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (76.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (13.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (56.7%)
• Flam. Liq. 3 (43.3%)
• Skin Corr. 1B (19.4%)
• Skin Irrit. 2 (76.1%)
• Eye Irrit. 2 (76.1%)
• STOT SE 3 (13.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.