Description

N,N-Diethylethanamine Trihydrofluoride (CAS No. 73602-61-6), also known as Triethylamine Trihydrofluoride, is a highly specialized fluorinating reagent widely used in organic synthesis and pharmaceutical research. This compound, with the molecular formula C₆H₁₈F₃N, is a stable, non-volatile alternative to anhydrous hydrogen fluoride (HF), offering safer handling while maintaining strong fluorination capabilities. It is particularly valued for its role in deprotection of silyl ethers, cleavage of silicon-oxygen bonds, and selective fluorination reactions. Packaged in high-purity form (98% or higher), it ensures consistent performance in sensitive applications. Ideal for researchers requiring precise control in fluorination steps without the extreme hazards of traditional HF.

Properties

• CAS Number: 73602-61-6
• Complexity: 25.7
• IUPAC Name: N,N-diethylethanamine;trihydrofluoride
• InChI: InChI=1S/C6H15N.3FH/c1-4-7(5-2)6-3;;;/h4-6H2,1-3H3;3*1H
• InChI Key: IKGLACJFEHSFNN-UHFFFAOYSA-N
• Exact Mass: 161.13913406
• Molecular Formula: C6H18F3N
• Molecular Weight: 161.21
• SMILES: CCN(CC)CC.F.F.F
• Topological: 3.2
• Monoisotopic Mass: 161.13913406
• Physical Description: Colorless liquid with a pungent odor; Hygroscopic;
• Synonyms: Triethylamine trihydrofluoride, N,N-Diethylethanamine trihydrofluoride, triethylamine trishydrofluoride, EINECS 277-550-5, DTXSID2074372, Ethanamine, N,N-diethyl-, hydrofluoride (1:3), DTXCID7047568, Ethanamine, N,Ndiethyl, trihydrofluoride, Ethanamine, N,Ndiethyl, hydrofluoride (1:3), un1790, 73602-61-6, Ethanamine, N,N-diethyl-, trihydrofluoride, MFCD00043294, N,N-diethylethanamine;trihydrofluoride, hydrogen fluoride in triethylamine, hf 37% in triethylamine, TREAT HF, ZX9Z7YP3AB, triethylaminetrihydrofluoride, trietylamine trihydrofluoride, SCHEMBL21513, triethylamine trihydroflouride, Triethylamine-trihydrofluoride, triethyl amine trihydrofluoride, Triethylamine trihydrof luoride, Triethylamine tris-hydrofluoride, triethylamine tris(hydrofluoride), BCP16967, Triethylamine trihydrofluoride, 98%, SBB087540, triethylamine tris(hydrogen fluoride), AKOS005063657, triethylazanium;fluoride;dihydrofluoride, DB-055781, triethylamine, fluoride, fluoride, fluoride, T2022, EN300-97327, F0001-1857, Triethylamine tri(hydrogen fluoride); Triethylamine Trihydrofluoride; Triethylamine Tris(hydrogen fluoride);

N,N-Diethylethanamine Trihydrofluoride is extensively used in organic synthesis for deprotecting tert-butyldimethylsilyl (TBDMS) and other silyl ethers under mild conditions. It serves as a safer alternative to HF in nucleophilic fluorination reactions, particularly in pharmaceutical intermediates. Additionally, it is employed in the preparation of fluorine-containing compounds for agrochemicals and materials science. Its stability and controlled reactivity make it a preferred choice for lab-scale and industrial processes requiring selective fluorination.

Safety and Hazards

GHS Hazard Statements

• H300 (98%): Fatal if swallowed [Danger Acute toxicity, oral]
• H310 (98%): Fatal in contact with skin [Danger Acute toxicity, dermal]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H330 (98%): Fatal if inhaled [Danger Acute toxicity, inhalation]

Precautionary Statements

• P260, P262, P264, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P320, P321, P330, P361+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 2 (98%)
• Acute Tox. 2 (98%)
• Skin Corr. 1A (100%)
• Acute Tox. 1 (98%)

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