Description

NMS-873 (CAS 1418013-75-8) is a high-purity, small-molecule inhibitor with the molecular formula C₂₇H₂₈N₄O₃S₂, designed for advanced research applications. This compound selectively targets p97/VCP (Valosin-Containing Protein), an essential AAA-ATPase involved in protein homeostasis, endoplasmic reticulum-associated degradation (ERAD), and autophagy pathways. With a purity of ≥98% (HPLC), NMS-873 is an invaluable tool for studying cancer biology, neurodegenerative diseases, and proteostasis dysregulation. Its robust inhibitory activity makes it ideal for in vitro and in vivo studies, offering researchers precise control over p97-mediated processes. Available in lyophilized form, this product is supplied with comprehensive analytical data (HPLC, MS) to ensure reproducibility and reliability in experimental settings.

Properties

• CAS Number: 1418013-75-8
• Complexity: 795
• IUPAC Name: 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine
• InChI: InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3
• InChI Key: UJGTUKMAJVCBIS-UHFFFAOYSA-N
• Exact Mass: 520.16028312
• Molecular Formula: C27H28N4O3S2
• Molecular Weight: 520.7
• SMILES: CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C
• Topological: 121
• Monoisotopic Mass: 520.16028312
• Synonyms: NMS-873, 1418013-75-8, NMS 873, 3-(3-(cyclopentylthio)-5-(((2-methyl-4′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)oxy)methyl)-4h-1,2,4-triazol-4-yl)pyridine, 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, NMS873, CHEMBL2311578, 3-(3-(cyclopentylthio)-5-(((2-methyl-4′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)oxy)methyl)-4H-1,2,4-triazol-4-yl)pyridine., 3-[3-(cyclopentylsulfanyl)-5-[({4′-methanesulfonyl-2-methyl-[1,1′-biphenyl]-4-yl}oxy)methyl]-4H-1,2,4-triazol-4-yl]pyridine, 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine, 3-[3-Cyclopentylsulfanyl-5-(4′-methanesulfonyl-2-methyl- biphenyl-4-yloxymethyl)-[1,2,4]triazol-4-yl]-pyridine, NM S873, Y6Y, MFCD28009371, SCHEMBL21981200, EX-A353, CHEBI:232809, GLXC-03842, HMS3653I08, HMS3744C07, BCP08666, BDBM50424917, NSC794522, NSC852513, s7285, AKOS026750235, CCG-269859, CS-2038, NSC-794522, NSC-852513, SB19506, NCGC00371131-02, NCGC00371131-03, NCGC00371131-09, NCGC00371131-12, 3-[3-Cyclopentylsulfanyl-5-(4′-methanesulfonyl-2-methylbiphenyl-4-yloxymethyl)-[1,2,4]triazol-4-yl]-pyridine, AC-32772, AS-16567, DA-45116, HY-15713, NMS-873, >=98% (HPLC), SW219853-1, BRD-K26253904-001-01-5, BRD-K26253904-001-03-1, 3-[3-(cyclopentylthio)-5-[[[2-methyl-4′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]oxy]methyl ]-4H-1,2,4-triazol-4-yl]-Pyridine

NMS-873 is widely used in oncology research to investigate p97/VCP’s role in tumor survival and drug resistance. It serves as a critical probe for studying ERAD inhibition in multiple myeloma and other protein aggregation disorders. Researchers also employ NMS-873 to explore autophagy modulation in neurodegenerative models like Alzheimer’s and Parkinson’s diseases. Its potent activity enables mechanistic studies of ubiquitin-proteasome system (UPS) dysregulation.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

Precautionary Statements

• P264, P270, P301+P317, P330, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.