Description

Nicosulfuron (CAS No. 111991-09-4) is a highly selective sulfonylurea herbicide with the molecular formula C₁₅H₁₈N₆O₆S. Its IUPAC name is 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-N,N-dimethylpyridine-3-carboxamide. This post-emergence herbicide is widely recognized for its efficacy in controlling a broad spectrum of grassy and certain broadleaf weeds in maize (corn) crops. Nicosulfuron acts by inhibiting the acetolactate synthase (ALS) enzyme, disrupting branched-chain amino acid synthesis, which leads to growth inhibition and eventual plant death. It is available under various trade names, including Milagro, Motivell, and Accent. Suitable for research and agricultural applications, this compound is characterized by its high purity, stability, and low use rates, making it an economical choice for weed management programs.

Properties

• CAS Number: 111991-09-4
• Complexity: 642
• IUPAC Name: 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-N,N-dimethyl-pyridine-3-carboxamide
• InChI: InChI=1S/C15H18N6O6S/c1-21(2)13(22)9-6-5-7-16-12(9)28(24,25)20-15(23)19-14-17-10(26-3)8-11(18-14)27-4/h5-8H,1-4H3,(H2,17,18,19,20,23)
• InChI Key: RTCOGUMHFFWOJV-UHFFFAOYSA-N
• LogP: log Kow: 0.35 at pH 5; 1.8 at pH 7; -2 at pH 9
• Exact Mass: 410.10085349
• Molecular Formula: C15H18N6O6S
• Molecular Weight: 410.4
• SMILES: CN(C)C(=O)C1=C(N=CC=C1)S(=O)(=O)NC(=O)NC2=NC(=CC(=N2)OC)OC
• Topological: 161
• Monoisotopic Mass: 410.10085349
• Color/Form: Colorless white solid
• Odor: Phenolic
• Melting Point: 172 °C
• Solubility: Solubilities : acetone 18, ethanol 4.5, chloroform, DMF 64, acetonitrile 23, toluene 0.370, hexane <0.02, dichloromethane 160
• Density: 9.53 g/mL
• Vapor Pressure: VP: 1.2X10-16 mm Hg at 25 °C
• Henry’s Law Constant: Henry’s Law constant = 4.13X10-18 atm-cu m/mol at 25 °C
• Dissociation Constants: pKa = 4.60
• Synonyms: Nicosulfuron, 111991-09-4, Milagro, Motivell, Accent (herbicide), Accent (pesticide), Nicosulfuron [ISO], SL 950, DPX-V 9360, HU 195, DPX-V9636, EPA Pesticide Chemical Code 129008, NOSTOC, CCRIS 9496, CHEBI:7554, DTXSID6034764, HSDB 7950, NICOSULFURON [MI], CG297D9264, 3-Pyridinecarboxamide, 2-(((((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)-N,N-dimethyl-, DTXCID4014764, DPX-V9360, MU-495, SL-950, 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-N,N-dimethylpyridine-3-carboxamide, 2-[(4,6-Dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-N,N-dimethylnicotinamide, 2-[[[[(4,6-Dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-N,N-dimethyl-3-pyridinecarboxamide, 2-((4,6-DIMETHOXYPYRIMIDIN-2-YLCARBAMOYL)SULFAMOYL)-N,N-DIMETHYLNICOTINAMIDE, 2-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N,N-dimethylpyridine-3-carboxamide, 2-(((((4,6-DIMETHOXY-2-PYRIMIDINYL)AMINO)CARBONYL)AMINO)SULFONYL)-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE, 3-Pyridinecarboxamide, 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-N,N-dimethyl-, 2-(((4,6-dimethoxypyrimidin-2-yl)carbamoyl)sulfamoyl)-N,N-dimethylpyridine-3-carboxamide, 2-((4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl)-N,N-dimethylpyridine-3-carboxamide, 2-((((4,6-Dimethoxy-(2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)-N,N-dimethyl-3-pyridinecarboxamide, USEPA/OPP Pesticide Code: 129008, 601-148-4, 686-897-5, 691-662-5, 2-(N-((4,6-Dimethoxypyrimidin-2-yl)carbamoyl)sulfamoyl)-N,N-dimethylnicotinamide, 2-({[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)-N,N-dimethylpyridine-3-carboxamide, 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-N,N-dimethyl-pyridine-3-carboxamide, Nicosulphuron, UNII-CG297D9264, Nicosulfuron; 2-[(4,6-Dimethoxypyrimidin-2-yl)carbamoylsulfamoyl]-N,N-dimethyl-pyridine-3-carboxamide, MFCD00203303, Nicosulfuron (Standard), SCHEMBL22938, CHEMBL2251450, HY-B1876R, HY-B1876, Tox21_301842, ZINC01532072, AKOS015851875, FN26193, KS-5068, NCGC00255581-01, AC-12593, DB-041026, CAS-111991-09-4, CS-0013942, NS00008411, Nicosulfuron, PESTANAL(R), analytical standard, Q1871615, 2-{[(4,6-Dimethoxy-2-pyrimidinyl)carbamoyl]sulfamoyl}-N,N-dimethylnicotinamide, 1-(4,6-Dimethoxy-2-pyrimidinyl)-3-[3-(dimethylcarbamoyl)-2-pyridylsulfonyl]urea; 2-[[(4,6-Dimethoxypyrimidin-2-yl) amino-carbonyl]am, 3-Pyridinecarboxamide, 2-(((((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)–N,N-dimethyl-

Application

Nicosulfuron is primarily used as a post-emergence herbicide for selective weed control in maize (corn) fields. It effectively targets grassy weeds such as barnyard grass, foxtail, and shattercane, as well as some broadleaf weeds. The herbicide is absorbed through foliage and roots, with systemic translocation throughout the plant. Its mode of action involves inhibition of the ALS enzyme, leading to disruption of plant growth. Nicosulfuron is favored for its low application rates and minimal environmental impact when used as directed.

Safety and Hazards

GHS Hazard Statements

• Not Classified
• Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website.

Precautionary Statements

• P273, P391, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (28.1%)
• Eye Irrit. 2 (27.5%)
• Aquatic Acute 1 (95%)
• Aquatic Chronic 1 (95%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.