Description

N,4-Dimethoxy-N-methylbenzamide (CAS No. 52898-49-4) is a high-purity organic compound with the molecular formula C₁₀H₁₃NO₃. This benzamide derivative features methoxy substituents at the N- and 4-positions, making it a valuable intermediate in synthetic organic chemistry and pharmaceutical research. With a molecular weight of 195.22 g/mol, it is supplied as a white to off-white crystalline powder with ≥98% purity (HPLC). Ideal for researchers exploring amide coupling reactions, heterocyclic synthesis, or drug discovery, this compound is meticulously packaged under inert conditions to ensure stability. Available in quantities ranging from milligrams to kilograms, it is accompanied by comprehensive analytical data (NMR, MS, HPLC) for quality assurance.

Properties

• CAS Number: 52898-49-4
• Complexity: 188
• IUPAC Name: N,4-dimethoxy-N-methyl-benzamide
• InChI: InChI=1S/C10H13NO3/c1-11(14-3)10(12)8-4-6-9(13-2)7-5-8/h4-7H,1-3H3
• InChI Key: FIRHLPVYIMMZPV-UHFFFAOYSA-N
• Exact Mass: 195.08954328
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.21
• SMILES: CN(C(=O)C1=CC=C(C=C1)OC)OC
• Topological: 38.8
• Monoisotopic Mass: 195.08954328
• Synonyms: N,4-DIMETHOXY-N-METHYLBENZAMIDE, 52898-49-4, DTXSID90568280, DTXCID30519054, 834-488-9, 4,N-Dimethoxy-N-methylbenzamide, 4-methoxy-n-methoxy-n-methylbenzamide, N,4-dimethoxy-N-methyl-benzamide, MFCD02684314, SCHEMBL286256, CHEMBL1860746, FIRHLPVYIMMZPV-UHFFFAOYSA-N, DNDI996469, AB9113, AKOS008953132, 4-methoxy-N-methoxy-N-methyl-benzamide, AS-44943, CS-0061701, D5475, F1903-0119

Application

N,4-Dimethoxy-N-methylbenzamide serves as a versatile building block in medicinal chemistry, particularly in the synthesis of bioactive molecules targeting neurological disorders. Its dual methoxy groups enhance electron density, facilitating electrophilic aromatic substitution reactions. Researchers also utilize it as a precursor for developing kinase inhibitors and GPCR modulators due to its rigid aromatic core and hydrogen-bonding capacity.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.