Description

N4-Acetylcytosine (CAS No. 14631-20-0) is a high-purity biochemical compound with the molecular formula C₆H₇N₃O₂ and IUPAC name N-(2-oxo-1H-pyrimidin-6-yl)acetamide. This modified nucleobase derivative is extensively utilized in nucleic acid research, epigenetics, and molecular biology applications. Our product is rigorously tested for purity (≥98% by HPLC) and stability, ensuring optimal performance in sensitive experiments. It is supplied as a white to off-white crystalline powder, soluble in DMSO and slightly soluble in water. Ideal for studying cytosine acetylation mechanisms, DNA/RNA modifications, and as a reference standard in analytical workflows. Store at 2-8°C in a dry environment to maintain integrity.

Properties

• CAS Number: 14631-20-0
• Complexity: 255
• IUPAC Name: N-(2-oxo-1H-pyrimidin-6-yl)acetamide
• InChI: InChI=1S/C6H7N3O2/c1-4(10)8-5-2-3-7-6(11)9-5/h2-3H,1H3,(H2,7,8,9,10,11)
• InChI Key: IJCKBIINTQEGLY-UHFFFAOYSA-N
• Exact Mass: 153.053826475
• Molecular Formula: C6H7N3O2
• Molecular Weight: 153.14
• SMILES: CC(=O)NC1=CC=NC(=O)N1
• Topological: 70.6
• Monoisotopic Mass: 153.053826475
• Synonyms: N4-Acetylcytosine, 619-683-7, 14631-20-0, N-(2-Oxo-1,2-dihydropyrimidin-4-yl)acetamide, N-Acetylcytosine, N-(2-oxo-1H-pyrimidin-6-yl)acetamide, n(4)-acetylcytosine, Acetamide, N-(1,2-dihydro-2-oxo-4-pyrimidinyl)-, MFCD00134466, Acetamide, N-(2,3-dihydro-2-oxo-4-pyrimidinyl)-, N-(2-hydroxypyrimidin-4-yl)acetamide, N-(2-oxo-2,3-dihydropyrimidin-4-yl)acetamide, N4 -acetylcytosine, 4-acetylamino-1,2-dihydro-2-pyrimidone, N-acetyl cytosine, NSC210403, N4-Acetylcytosine, 99%, SCHEMBL21187, SCHEMBL536836, SCHEMBL655272, SCHEMBL5632484, SCHEMBL5632488, SCHEMBL9015494, SCHEMBL9015496, CHEMBL3273673, IJCKBIINTQEGLY-UHFFFAOYSA-, DTXSID30163354, CHEBI:146134, BCP12969, SBB056646, 4-(acetylamino)pyrimidine-2(1H)-one, AKOS006227633, AKOS015837993, AKOS022634962, AC-8695, CS-W010939, FA05993, HY-W010223, N-(2-oxohydropyrimidin-4-yl)acetamide, NSC 210403, NSC-210403, N-(2-oxo-3H-pyrimidin-4-yl)acetamide, AS-12395, ST094959, SY069214, DB-030107, A2089, F16463, N-(1,2-dihydro-2-oxo-4-pyrimidinyl)acetamide, N-(2-Oxo-1,2-dihydro-4-pyrimidinyl)acetamide, EN300-6808778, Q20892014, InChI=1/C6H7N3O2/c1-4(10)8-5-2-3-7-6(11)9-5/h2-3H,1H3,(H2,7,8,9,10,11)

Application

N4-Acetylcytosine serves as a critical tool in epigenetic research, particularly for investigating post-transcriptional RNA modifications and their regulatory roles. It is employed as a synthetic precursor for modified oligonucleotides in structural biology studies. Researchers also utilize this compound to explore enzymatic acetylation pathways in nucleic acid metabolism. Its stability under physiological conditions makes it suitable for in vitro modeling of epigenetic markers.

Safety and Hazards

GHS Hazard Statements

• H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (85.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.