Description

N2-Tritylolmesartan medoxomil (CAS No. 1020157-01-0) is a high-purity synthetic intermediate used in pharmaceutical research and development, particularly in the synthesis of angiotensin II receptor blockers (ARBs). This compound features the molecular formula C₄₈H₄₄N₆O₆ and a systematic IUPAC name of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate. Its trityl-protected tetrazole moiety enhances stability during synthetic processes, making it ideal for controlled derivatization in API manufacturing. Supplied as a fine white to off-white powder, it is characterized by HPLC purity ≥95% and is stored under inert conditions to ensure long-term stability. Suitable for lab-scale and process optimization, this compound is packaged in amber glass vials with certificated analysis.

Properties

• CAS Number: 1020157-01-0
• Complexity: 1420
• IUPAC Name: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate
• InChI: InChI=1S/C48H44N6O6/c1-5-17-41-49-43(47(3,4)57)42(45(55)58-31-40-32(2)59-46(56)60-40)53(41)30-33-26-28-34(29-27-33)38-24-15-16-25-39(38)44-50-52-54(51-44)48(35-18-9-6-10-19-35,36-20-11-7-12-21-36)37-22-13-8-14-23-37/h6-16,18-29,57H,5,17,30-31H2,1-4H3
• InChI Key: KKYFOXOGKNDKRS-UHFFFAOYSA-N
• Exact Mass: 800.33223314
• Molecular Formula: C48H44N6O6
• Molecular Weight: 800.9
• SMILES: CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN(N=N4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)C(=O)OCC8=C(OC(=O)O8)C)C(C)(C)O
• Topological: 143
• Monoisotopic Mass: 800.33223314
• Synonyms: 1020157-01-0, N2-Tritylolmesartan medoxomil, N2-Trityl olmesartan medoxomil, UNII-KIU4Z454AM, KIU4Z454AM, Olmesartan medoxomil impurity D [EP], (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2′-((2-triphenylmethyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate, 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2′-(2-(triphenylmethyl)-2H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, OLMESARTAN MEDOXOMIL IMPURITY D [EP IMPURITY], OLMESARTAN MEDOXOMIL IMPURITY D (EP IMPURITY), Olmesartan medoxomil impurity D, N-2 Trityl Olmesartan Medoxomil, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate, (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(2-trityl-2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, SCHEMBL94332, IH139102, Q27282272, 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-(5-methyl-2-oxo-1,3-d ioxol-4-yl)1H-Imidazole-5-carboxylic acid methyl ester, N-2Trityl olmesartan medoxomil;Olmesartan impurity D;5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3-[2′-(2-trityl-2H-tetrazol-5-yl)-bipheny l-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Application

N2-Tritylolmesartan medoxomil serves as a critical precursor in the synthesis of Olmesartan medoxomil, a potent antihypertensive drug. Researchers utilize this intermediate for selective deprotection studies and structural modifications to improve drug bioavailability. Its application extends to analytical method development and impurity profiling in ARB-class active pharmaceutical ingredients (APIs).

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