Description

N,2-dimethoxy-N-methylacetamide (CAS No. 132289-57-7) is a high-purity specialty chemical with the molecular formula C₅H₁₁NO₃. This compound, also known as N-Methoxy-N-methyl-2-methoxyacetamide, is an advanced amide derivative featuring dual methoxy functional groups, making it a valuable reagent in organic synthesis and pharmaceutical research. Its unique structure offers excellent solvation properties and reactivity in nucleophilic substitution reactions. Ideal for researchers requiring precise and controlled amidation or transamidation processes, this product is rigorously tested for purity and consistency. Available in various quantities, it is supplied with comprehensive analytical data including GC/MS, NMR, and HPLC reports to ensure compliance with laboratory standards.

Properties

• CAS Number: 132289-57-7
• Complexity: 94.2
• IUPAC Name: N,2-dimethoxy-N-methyl-acetamide
• InChI: InChI=1S/C5H11NO3/c1-6(9-3)5(7)4-8-2/h4H2,1-3H3
• InChI Key: YFNOEDJHRRXTRH-UHFFFAOYSA-N
• Exact Mass: 133.07389321
• Molecular Formula: C5H11NO3
• Molecular Weight: 133.15
• SMILES: CN(C(=O)COC)OC
• Topological: 38.8
• Monoisotopic Mass: 133.07389321
• Synonyms: N,2-dimethoxy-N-methylacetamide, 132289-57-7, N-Methoxy-N-methyl-2-methoxyacetamide, Acetamide, N,2-dimethoxy-N-methyl-, MFCD11848891, SCHEMBL1558801, 2,N-Dimethoxy-N-methylacetamide, 2,N-dimethoxy-N-methyl-acetamide, N, 2-dimethoxy-N-methylacetamide, N,2-dimethoxy-N-methyl-acetamide, YFNOEDJHRRXTRH-UHFFFAOYSA-N, AKOS009147769, AS-63042, DA-12313, SY224288, CS-0061704, W16959, F1903-0103

Application

N,2-dimethoxy-N-methylacetamide is widely used as a versatile intermediate in organic synthesis, particularly in the preparation of complex amides and esters. It serves as a key building block in pharmaceutical research for the development of active pharmaceutical ingredients (APIs) and prodrugs. Additionally, its solvation properties make it suitable for use in specialty solvents and reaction media for polar substrates. Researchers also employ it in peptide coupling reactions and as a protecting group reagent in multistep synthetic pathways.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.