Description

N10-(Trifluoroacetyl)pteroic acid (CAS No. 37793-53-6) is a high-purity biochemical compound with the molecular formula C₁₆H₁₁F₃N₆O₄. This trifluoroacetyl derivative of pteroic acid is a key intermediate in folate metabolism research, offering exceptional stability and reactivity for synthetic applications. With a purity of ≥95%, it is ideal for pharmaceutical development, enzymatic studies, and biochemical assays. The compound features a benzoic acid moiety linked to a pteridinylmethyl group via a trifluoroacetamido bridge, enhancing its utility in probing folate-dependent pathways. Packaged under inert conditions to ensure longevity, this product is suited for researchers requiring precise and reproducible results in their experiments.

Properties

• CAS Number: 37793-53-6
• Complexity: 707
• IUPAC Name: 4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-(2,2,2-trifluoroacetyl)amino]benzoic acid
• InChI: InChI=1S/C16H11F3N6O4/c17-16(18,19)14(29)25(9-3-1-7(2-4-9)13(27)28)6-8-5-21-11-10(22-8)12(26)24-15(20)23-11/h1-5H,6H2,(H,27,28)(H3,20,21,23,24,26)
• InChI Key: IJGIHDXKYQLIMA-UHFFFAOYSA-N
• Exact Mass: 408.07938734
• Molecular Formula: C16H11F3N6O4
• Molecular Weight: 408.29
• SMILES: C1=CC(=CC=C1C(=O)O)N(CC2=CN=C3C(=N2)C(=O)NC(=N3)N)C(=O)C(F)(F)F
• Topological: 151
• Monoisotopic Mass: 408.07938734
• Synonyms: 37793-53-6, N10-(Trifluoroacetyl)pteroic acid, 4-(N-((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)-2,2,2-trifluoroacetamido)benzoic acid, n10-trifluoroacetylpteroic acid, 4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-(2,2,2-trifluoroacetyl)amino]benzoic Acid, CHEMBL46163, MFCD00006707, 4-(N-((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)-methyl)-2,2,2-trifluoroacetamido)benzoic acid, 4-{N-[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]-2,2,2-trifluoroacetamido}benzoic acid, 4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl](2,2,2-trifluoroacetyl)amino]benzoic acid, 4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl](2,2,2-trifluoroacetyl)amino]benzoic Acid; 4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl](trifluoroacetyl)amino]benzoic Acid, 4-[N-[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]-2,2,2-trifluoroacetamido]benzoic Acid, 4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-(2,2,2-trifluoroacetyl)amino]benzoic acid, SCHEMBL1229438, SCHEMBL1230279, SCHEMBL12867928, 10-(trifluoroacetyl)pteroic acid, DTXSID50403885, N10 -Trifluoroacetylpteroic Acid, BCP04835, EX-A2651, BDBM50099676, AKOS015901780, AKOS015995563, FT30146, N(sup 10)-(trifluoroacetyl)pteroic acid, AC-35294, AS-60426, N10-(Trifluoroacetyl)pteroic acid, 95%, ST056385, SY323274, DB-008648, CS-0011062, 4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid, 4-[(2-Amino-4-hydroxypteridin-6-ylmethyl)-(2,2,2-trifluoroacetyl)amino]benzoic acid, 4-{N-[(2-amino-4-oxo(8-hydropteridin-6-yl))methyl]-2,2,2-trifluoroacetylamino} benzoic acid

N10-(Trifluoroacetyl)pteroic acid is widely used in biochemical research as a precursor in folate analog synthesis, enabling studies on antifolate drug mechanisms. Its stability makes it valuable for enzyme inhibition assays targeting dihydrofolate reductase (DHFR). Researchers also employ it to investigate folate transport and metabolism in cellular systems, particularly in cancer therapeutics development.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H350 (100%): May cause cancer [Danger Carcinogenicity]

Precautionary Statements

• P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (100%)
• Carc. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.