Description

N1-Methyl-4-(trifluoromethyl)benzene-1,2-diamine (CAS No. 35203-49-7) is a high-purity specialty chemical with the molecular formula C₈H₉F₃N₂. This compound is an advanced intermediate widely used in pharmaceutical research, agrochemical synthesis, and material science applications. Its unique trifluoromethyl and diamine functional groups make it a versatile building block for heterocyclic compounds, catalysts, and fluorinated polymers. Available in >98% purity (HPLC), it is supplied as a crystalline solid with strict quality control to ensure batch-to-batch consistency. Ideal for medicinal chemistry applications, this product is packaged under inert gas in amber glass vials to ensure stability. SDS and analytical certificates (COA, NMR, MS) are provided.

Properties

• CAS Number: 35203-49-7
• Complexity: 169
• IUPAC Name: N1-methyl-4-(trifluoromethyl)benzene-1,2-diamine
• InChI: InChI=1S/C8H9F3N2/c1-13-7-3-2-5(4-6(7)12)8(9,10)11/h2-4,13H,12H2,1H3
• InChI Key: KWYSQBACVABOFL-UHFFFAOYSA-N
• Exact Mass: 190.07178278
• Molecular Formula: C8H9F3N2
• Molecular Weight: 190.17
• SMILES: CNC1=C(C=C(C=C1)C(F)(F)F)N
• Topological: 38.1
• Monoisotopic Mass: 190.07178278
• Synonyms: n1-methyl-4-(trifluoromethyl)benzene-1,2-diamine, 35203-49-7, DTXSID00351968, DTXCID10303034, 640-310-9, 1-N-methyl-4-(trifluoromethyl)benzene-1,2-diamine, 3,4-Diamino-N4-methylbenzotrifluoride, MFCD01571385, N~1~-methyl-4-(trifluoromethyl)benzene-1,2-diamine, [2-amino-4-(trifluoromethyl)phenyl]methylamine, 1,2-Benzenediamine, N1-methyl-4-(trifluoromethyl)-, N1-methyl-4-trifluoromethylbenzene-1,2-diamine, SCHEMBL115650, N-[2-Amino-4-(trifluoromethyl)-phenyl]-N-methylamine, CHEMBL5419284, ALBB-026237, 3-amino-4-methylaminobenzotrifluoride, SBB072931, STK664200, AKOS005535661, PS-10963, SY271715, ST4094122, CS-0046909, W11084, N1-Methyl-4-trifluoromethyl-benzene-1,2-diamine, N-1-Methyl-4-trifluoromethyl-benzene-1,2-diamine, N1-Methyl-4-(trifluoromethyl)-1,2-benzenediamine, 1,2-benzenediamine, N~1~-methyl-4-(trifluoromethyl)-, F2167-8488, U43

This compound serves as a key precursor in the synthesis of trifluoromethyl-substituted benzimidazoles for kinase inhibitor development. It is also used in cross-coupling reactions to create fluorinated dyes and OLED materials. Researchers employ it as a ligand in asymmetric catalysis and as a monomer for high-performance fluoropolymers.

Safety and Hazards

GHS Hazard Statements

• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]

Precautionary Statements

• P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P321, P330, P361+P364, P403+P233, P405, and P501

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