Description

N-Trimethylsilyl-N-methylacetamide (CAS No. 7449-74-3) is a high-purity silylated amide compound with the molecular formula C₆H₁₅NOSi. This specialized reagent is widely used in organic synthesis, particularly as a silylating agent for the protection of sensitive functional groups. Its unique structure, featuring a trimethylsilyl (TMS) group bonded to a methylacetamide backbone, provides excellent reactivity in nucleophilic substitutions and other transformations. Ideal for peptide chemistry, carbohydrate derivatization, and heterocycle synthesis, this product is rigorously tested to ensure ≥98% purity (GC) and is supplied in moisture-free packaging to maintain stability. Suitable for advanced research in pharmaceuticals, agrochemicals, and material science.

Properties

• CAS Number: 7449-74-3
• Complexity: 117
• IUPAC Name: N-methyl-N-trimethylsilyl-acetamide
• InChI: InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3
• InChI Key: QHUOBLDKFGCVCG-UHFFFAOYSA-N
• Exact Mass: 145.092290636
• Molecular Formula: C6H15NOSi
• Molecular Weight: 145.27
• SMILES: CC(=O)N(C)[Si](C)(C)C
• Topological: 20.3
• Monoisotopic Mass: 145.092290636
• Synonyms: N-Methyl-N-(trimethylsilyl)acetamide, 7449-74-3, Acetamide, N-methyl-N-(trimethylsilyl)-, N-Trimethylsilyl-N-methylacetamide, W0IWF6UKW5, EINECS 231-217-0, NSC 142435, NSC-142435, DTXSID0064707, DTXCID2047694, 231-217-0, N-Methyl-N-trimethylsilylacetamide, N-Methyl-N-TMS-acetamide, N-Methyl-N-trimethylsilyacetamide, MFCD00040758, N-Methylacetamide, TMS derivative, N-Methyl-N-trimethylsilylacetamide (>85%), N-Trimethylsilyl-N-methylacetamide; NSC 142435, NSC142435, UNII-W0IWF6UKW5, SCHEMBL537585, QHUOBLDKFGCVCG-UHFFFAOYSA-, N-trimethylsilyl-N’-methylacetamide, AKOS006229818, FM61105, FS-4239, SY049706, DB-002831, CS-0179366, M0536, NS00047387, D91352, InChI=1/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3, N-Methyl-N-trimethylsilylacetamide, for GC derivatization, >=97.0% (GC)

Application

N-Trimethylsilyl-N-methylacetamide is primarily employed as a versatile silylating agent in the protection of amines, alcohols, and carboxylic acids during multi-step syntheses. It facilitates the preparation of volatile derivatives for GC-MS analysis, particularly in metabolomics and drug metabolite studies. The compound also serves as a key intermediate in the synthesis of silicon-containing polymers and specialty silicones.

Safety and Hazards

GHS Hazard Statements

• H226 (94.1%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (52.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (11.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (47.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (52.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H360D (11.8%): May damage the unborn child [Danger Reproductive toxicity]

Precautionary Statements

• P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P317, P318, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (94.1%)
• Skin Irrit. 2 (52.9%)
• Eye Dam. 1 (11.8%)
• Eye Irrit. 2 (47.1%)
• STOT SE 3 (52.9%)
• Repr. 1B (11.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.