Description

N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a high-purity silylation reagent widely used in analytical chemistry for derivatization of polar compounds to enhance their volatility and detectability in gas chromatography (GC) and mass spectrometry (MS). With the molecular formula C₆H₁₂F₃NOSi and CAS number 24589-78-4, this reagent is particularly effective for modifying hydroxyl, carboxyl, and amine groups, making it indispensable in metabolomics, pharmaceutical analysis, and environmental testing. MSTFA is known for its rapid reaction kinetics, excellent derivatization efficiency, and compatibility with sensitive detection methods. Packaged under inert conditions to ensure stability, our MSTFA is rigorously tested for purity and performance, making it a reliable choice for researchers requiring precise and reproducible results.

Properties

• CAS Number: 24589-78-4
• Complexity: 184
• IUPAC Name: 2,2,2-trifluoro-N-methyl-N-trimethylsilyl-acetamide
• InChI: InChI=1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3
• InChI Key: MSPCIZMDDUQPGJ-UHFFFAOYSA-N
• Exact Mass: 199.06402503
• Molecular Formula: C6H12F3NOSi
• Molecular Weight: 199.25
• SMILES: CN(C(=O)C(F)(F)F)[Si](C)(C)C
• Topological: 20.3
• Monoisotopic Mass: 199.06402503
• Physical Description: Colorless liquid;
• Synonyms: 24589-78-4, N-Methyl-N-(trimethylsilyl)trifluoroacetamide, MSTFA, 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide, N-Methyl-N-trimethylsilyltrifluoroacetamide, ACETAMIDE, 2,2,2-TRIFLUORO-N-METHYL-N-(TRIMETHYLSILYL)-, EINECS 246-331-6, NSC 339701, BRN 1941550, DTXSID5067003, CHEBI:85064, N-methyl(trimethylsilyl)trifluoroacetamide, n-(trimethylsilyl)-n-methyltrifluoroacetamide, DTXCID5037101, NMethylNtrimethylsilyltrifluoroacetamide, Acetamide, 2,2,2trifluoroNmethylN(trimethylsilyl), 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl) acetamide, 246-331-6, MFCD00000411, 2,2,2-trifluoro-N-methyl-N-trimethylsilylacetamide, N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 97%, n-methyl-n-trimethylsilyl trifluoroacetamide, N-Trimethylsilyl-N-methyl trifluoroacetamide, N-Methyl-N-(trimethyl-d9-silyl)trifluoroacetamide, MSTFA; N-Methyl-N-(trimethylsilyl)trifluoroacetamide, MSTFA Reagent, N-METHYL-N-(TRIMETHYLSILYL)-TRIFLUOROACETAMIDE, SCHEMBL231141, SCHEMBL11270523, CM9160, NSC339701, AKOS005762921, HY-W089645, NSC-339701, AS-17584, PD065582, SY009684, N-Methyltrifluoroacetamide, TMS derivative, DB-030202, n-methyl-n-trimethylsilyl-trifluoroacetamide, M0672, NS00049373, N-methyl-N-(trimethylsilyl)trifluoro-acetamide, N-Methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide, Acetamide,2,2-trifluoro-N-methyl-N-(trimethylsilyl)-, Q27158313, 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide #, MSTFA Reagent, ampule of 10 x 1.2 mL, analytical standard, N-Methyl-N-(trimethylsilyl)trifluoroacetamide, synthesis grade, N-Methyl-N-(trimethylsilyl)trifluoroacetamide, purum, >=97.0% (GC), N-Methyl-N-(trimethylsilyl)trifluoroacetamide, BioReagent, suitable for silylation, N-Methyl-N-(trimethylsilyl)trifluoroacetamide, for GC derivatization, >=98.5%, N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane, for GC derivatization

Application

MSTFA is primarily used as a derivatizing agent in gas chromatography (GC) and GC-MS applications to improve the volatility and thermal stability of polar compounds such as sugars, amino acids, and steroids. It is especially valuable in metabolomics for profiling low-molecular-weight metabolites, enabling accurate quantification and identification. Additionally, MSTFA is employed in pharmaceutical quality control to analyze drug metabolites and impurities with high sensitivity.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.