Description

N-Methoxy-N-methylpropionamide (CAS: 104863-65-2) is a high-purity synthetic amide derivative widely utilized in organic synthesis and pharmaceutical research. With the molecular formula C₅H₁₁NO₂, this compound serves as a versatile reagent, particularly in the preparation of Weinreb amides, enabling controlled ketone and aldehyde synthesis. Its stable, liquid form ensures easy handling and compatibility with a broad range of solvents, making it ideal for laboratory and industrial applications. Rigorous quality control guarantees >98% purity (HPLC), minimizing side reactions and maximizing yield in complex transformations. Suitable for use under inert conditions, it is packaged in sealed amber vials to prevent degradation.

Properties

• CAS Number: 104863-65-2
• Complexity: 82.5
• IUPAC Name: N-methoxy-N-methyl-propanamide
• InChI: InChI=1S/C5H11NO2/c1-4-5(7)6(2)8-3/h4H2,1-3H3
• InChI Key: YKVJZSZZQKQJMO-UHFFFAOYSA-N
• Exact Mass: 117.078978594
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.15
• SMILES: CCC(=O)N(C)OC
• Topological: 29.5
• Monoisotopic Mass: 117.078978594
• Synonyms: N-Methoxy-N-methylpropionamide, 104863-65-2, DTXSID60462887, DTXCID90413706, 833-755-7, N-methoxy-N-methylpropanamide, N-METHOXY-N-METHYL-PROPIONAMIDE, MFCD09833541, N-Methyl-N-methoxypropanamide, SCHEMBL26558, SCHEMBL209809, SCHEMBL2722274, N-Methoxy-N-methylisopropanamide, YKVJZSZZQKQJMO-UHFFFAOYSA-N, AR3350, AKOS008953072, propionic acid N-methoxy-N-methylamide, DS-6631, SY104588, DB-298785, CS-0122993, M3096, EN300-206285

N-Methoxy-N-methylpropionamide is primarily employed as a key intermediate in the synthesis of Weinreb amides, facilitating the controlled formation of ketones and aldehydes from esters or acid chlorides. Its applications extend to peptide coupling reactions and as a protecting group in multistep organic syntheses. Researchers also utilize it in the development of pharmaceuticals and agrochemicals due to its stability and reactivity under mild conditions.

Safety and Hazards

GHS Hazard Statements

• H225 (33.3%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H226 (66.7%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (33.3%)
• Flam. Liq. 3 (66.7%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2A (66.7%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.