Description

N-methoxy-N-methyloxane-4-carboxamide (CAS: 156353-01-4) is a high-purity synthetic amide derivative with the molecular formula C8H15NO3. This compound is widely utilized in organic synthesis, pharmaceutical research, and material science due to its versatile reactivity as a Weinreb amide intermediate. Its stable tetrahydropyran backbone and N-methoxy-N-methyl functional group make it an excellent precursor for the controlled formation of ketones and aldehydes via nucleophilic addition reactions. With a molecular weight of 173.21 g/mol, this white to off-white crystalline solid is characterized by exceptional purity (>98%) and low moisture content, ensuring optimal performance in sensitive applications. Suitable for HPLC, LC-MS, and NMR analysis, it is packaged under inert conditions to guarantee stability and longevity.

Properties

• CAS Number: 156353-01-4
• Complexity: 154
• IUPAC Name: N-methoxy-N-methyl-tetrahydropyran-4-carboxamide
• InChI: InChI=1S/C8H15NO3/c1-9(11-2)8(10)7-3-5-12-6-4-7/h7H,3-6H2,1-2H3
• InChI Key: QURBKRFUFINPQC-UHFFFAOYSA-N
• Exact Mass: 173.10519334
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.21
• SMILES: CN(C(=O)C1CCOCC1)OC
• Topological: 38.8
• Monoisotopic Mass: 173.10519334
• Synonyms: 156353-01-4, N-METHOXY-N-METHYLOXANE-4-CARBOXAMIDE, DTXSID80630965, DTXCID90581717, 825-335-7, N-Methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide, N-Methoxy-N-methyltetrahydropyran-4-carboxamide, 2H-Pyran-4-carboxamide, tetrahydro-N-methoxy-N-methyl-, MFCD07370048, TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID METHOXY-METHYL-AMIDE, SCHEMBL11805, N-methoxy-N-methyl-tetrahydro-2H-pyran-4-carboxamide, QURBKRFUFINPQC-UHFFFAOYSA-N, AKOS009129407, AB32506, AS-41622, SY015948, DB-021534, CS-0037535, EN300-135035, N-methoxy-N-methyl-tetrahydropyran-4-carboxamide, F1903-0260, n-methoxy-n-methyl tetrahydropyran-4-carboxylic acid amide

N-methoxy-N-methyloxane-4-carboxamide serves as a critical building block in medicinal chemistry for the synthesis of bioactive molecules, particularly in the development of protease inhibitors and receptor modulators. Its role as a Weinreb amide enables precise carbonyl group transformations, making it invaluable in peptide mimetics and heterocyclic compound synthesis. Researchers also employ it in material science for designing functionalized polymers and advanced coatings.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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