Description

N-Methoxy-N-methylcyclopropanecarboxamide (CAS: 147356-78-3) is a high-purity cyclopropane-derived carboxamide compound with the molecular formula C₆H₁₁NO₂. This specialty chemical is widely utilized in pharmaceutical research, agrochemical synthesis, and organic chemistry applications due to its unique structural properties as a N-methoxy-N-methylamide derivative. The compound is supplied as a stable, crystalline solid with ≥95% purity (HPLC), ensuring consistency for demanding synthetic workflows. Its cyclopropane ring system offers distinct steric and electronic characteristics valuable for medicinal chemistry optimization and ligand design. Proper storage under inert atmosphere at 2-8°C is recommended for long-term stability.

Key applications include:

• Versatile building block for cyclopropane-containing bioactive molecules
• Weinreb amide equivalent for controlled carbonyl additions
• Intermediate in synthetic routes to pharmaceuticals and crop protection agents

Technical specifications include:

Molecular Weight:	129.16 g/mol
Melting Point:	45-48°C
Boiling Point:	~220°C (est.)
Density:	1.08 g/cm3 (predicted)

Properties

• CAS Number: 147356-78-3
• Complexity: 120
• IUPAC Name: N-methoxy-N-methyl-cyclopropanecarboxamide
• InChI: InChI=1S/C6H11NO2/c1-7(9-2)6(8)5-3-4-5/h5H,3-4H2,1-2H3
• InChI Key: IQYRPZAMBNATNQ-UHFFFAOYSA-N
• Exact Mass: 129.078978594
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.16
• SMILES: CN(C(=O)C1CC1)OC
• Topological: 29.5
• Monoisotopic Mass: 129.078978594
• Synonyms: N-Methoxy-N-methylcyclopropanecarboxamide, 147356-78-3, DTXSID00576199, DTXCID40526971, 857-153-9, Cyclopropanecarboxamide, N-methoxy-N-methyl-, N-methoxy-N-methyl-Cyclopropanecarboxamide, MFCD11845572, Cyclopropanecarboxylic acid methoxy-methyl-amide, SCHEMBL428708, SCHEMBL1927454, IQYRPZAMBNATNQ-UHFFFAOYSA-N, XFA35678, AKOS008953237, n-methoxy-n-methylcyclopropylcarboxamide, cyclopropyl-n-methoxy-n-methylcarboxamide, N-methyl-N-methoxycyclopropanecarboxamide, AC-31157, DS-17097, SY013330, DB-063703, CS-0048809, N-Methyl-N-(methyloxy)cyclopropanecarboxamide, EN300-205488, cyclopropanecarboxylic acid N,O-dimethylhydroxylamide

N-Methoxy-N-methylcyclopropanecarboxamide serves as a critical intermediate in medicinal chemistry for the development of cyclopropane-containing drug candidates. The Weinreb amide functionality enables controlled ketone synthesis through organometallic additions. Researchers employ this compound in fragment-based drug design due to its constrained geometry and hydrogen bonding capabilities. Its stability makes it particularly valuable for multi-step synthetic sequences in pharmaceutical R&D.

Safety and Hazards

GHS Hazard Statements

• H226 (50%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (50%)
• Acute Tox. 4 (100%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (50%)
• Eye Irrit. 2A (50%)
• Acute Tox. 4 (50%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.