Description

N-Methoxy-N-methylbenzamide (CAS No. 6919-61-5) is a high-purity synthetic organic compound with the molecular formula C₉H₁₁NO₂. This versatile amide derivative is widely utilized in pharmaceutical research, agrochemical synthesis, and as a key intermediate in organic transformations. Our product is rigorously tested to ensure ≥98% purity by HPLC, with stringent quality control for batch-to-batch consistency. The white to off-white crystalline powder exhibits excellent solubility in common organic solvents (DMSO, DMF, methanol) while being sparingly soluble in water. Each batch is accompanied by comprehensive analytical documentation including ¹H NMR, ¹³C NMR, and mass spectrometry data. Ideal for: • Weinreb amide applications • Peptide mimetics • Metal-chelating agent development • Nucleophilic acyl substitution reactions. Packaged under inert atmosphere in amber glass vials with PTFE-lined caps to ensure long-term stability. Available in research quantities (100mg-1g) through bulk industrial scales (1kg+).

Properties

• CAS Number: 6919-61-5
• Complexity: 153
• IUPAC Name: N-methoxy-N-methyl-benzamide
• InChI: InChI=1S/C9H11NO2/c1-10(12-2)9(11)8-6-4-3-5-7-8/h3-7H,1-2H3
• InChI Key: UKERDACREYXSIV-UHFFFAOYSA-N
• Exact Mass: 165.078978594
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.19
• SMILES: CN(C(=O)C1=CC=CC=C1)OC
• Topological: 29.5
• Monoisotopic Mass: 165.078978594
• Synonyms: N-Methoxy-N-methylbenzamide, 6919-61-5, N-Methyl-N-methoxybenzamide, methyl N-methylbenzohydroxamate, CHEBI:59742, DTXSID80341044, DTXCID00292125, 805-987-9, ukerdacreyxsiv-uhfffaoysa-n, MFCD00075320, N-methoxy-N-methyl-benzamide, n-methyl-n-methoxy benzamide, Benzamide, N-methoxy-N-methyl-, N-methoxy-N-methylbenzamid, N-methoxy-N-methyl benzamide, SCHEMBL28777, SCHEMBL1642736, SCHEMBL1642738, SCHEMBL10841502, N-Methoxy-N-methylbenzamide, 98%, GAA91961, BBL101465, N-methoxy-N-methyl-benzenecarboxamide, STL555261, AKOS005259450, AB11569, CS-W017890, SB76635, N-Methylbenzohydroxamic acid methyl ester, AS-11249, N-benzoyl-N-methyl-O-methyl-hydroxylamine, SY052485, DB-030199, M2672, EN300-317668, Q27126879, F1903-0112

N-Methoxy-N-methylbenzamide serves as a crucial Weinreb amide precursor for controlled ketone synthesis via organometallic reagent addition. In medicinal chemistry, it facilitates the construction of bioactive scaffolds through selective acylation reactions. The compound’s stability under basic conditions makes it valuable for multi-step synthetic sequences. Researchers employ it as a directing group in C-H activation protocols and as a masked carboxylic acid equivalent. Its chelating properties are exploited in asymmetric catalysis and transition metal-mediated transformations.

Safety and Hazards

GHS Hazard Statements

• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2 (66.7%)
• STOT SE 3 (33.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.