Description

N-(4-bromo-2-fluorophenyl)acetamide (CAS No. 326-66-9) is a high-purity organic compound with the molecular formula C₈H₇BrFNO. This specialized chemical is widely utilized in pharmaceutical research, agrochemical development, and material science due to its unique halogenated aromatic structure. The compound features a bromo-fluoro substitution pattern on the phenyl ring, making it a valuable intermediate for Suzuki coupling reactions and other cross-coupling methodologies.

Our product is synthesized under strict quality control measures, ensuring ≥98% purity by HPLC analysis. It is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Each shipment includes comprehensive analytical documentation including ¹H NMR, ¹³C NMR, and mass spectrometry data for verification.

Special storage conditions: Store in a cool, dry place at 2-8°C under inert atmosphere. Suitable for use in medicinal chemistry, drug discovery programs, and as a building block for advanced materials.

Properties

• CAS Number: 326-66-9
• Complexity: 176
• IUPAC Name: N-(4-bromo-2-fluoro-phenyl)acetamide
• InChI: InChI=1S/C8H7BrFNO/c1-5(12)11-8-3-2-6(9)4-7(8)10/h2-4H,1H3,(H,11,12)
• InChI Key: BCYGKMDWQBWUSC-UHFFFAOYSA-N
• Exact Mass: 230.96950
• Molecular Formula: C8H7BrFNO
• Molecular Weight: 232.05
• SMILES: CC(=O)NC1=C(C=C(C=C1)Br)F
• Topological: 29.1
• Monoisotopic Mass: 230.96950
• Synonyms: N-(4-Bromo-2-fluorophenyl)acetamide, 326-66-9, 4′-Bromo-2′-fluoroacetanilide, Acetamide, N-(4-bromo-2-fluorophenyl)-, W3HCD2QTE4, EINECS 206-314-6, DTXSID60186293, 2′-FLUORO-4′-BROMOACETANILIDE, DTXCID70108784, 206-314-6, 4-Bromo-2-fluoroacetanilide, MFCD00042588, N-(4-bromo-2-fluoro-phenyl)acetamide, UNII-W3HCD2QTE4, SCHEMBL3472841, N-Acetyl-2-fluoro-4-bromoaniline, SBB009911, STL482893, AKOS000190277, 4′-Bromo-2′-fluoroacetanilide, 99%, AS-9192, N-(4-Bromo-2-fluoro-phenyl)-acetamide, N-(4-Bromo-2-fluorophenyl)acetamide #, AC-15661, ST060487, SY048664, B1440, CS-0204627, NS00041840, AO-548/40948685, Z30824336, 4 inverted exclamation mark -Bromo-2 inverted exclamation mark -fluoroacetanilide, InChI=1/C8H7BrFNO/c1-5(12)11-8-3-2-6(9)4-7(8)10/h2-4H,1H3,(H,11,12

Application

N-(4-bromo-2-fluorophenyl)acetamide serves as a key synthetic intermediate in pharmaceutical research, particularly in the development of novel bioactive molecules. The compound’s unique halogen substitution pattern makes it valuable for creating targeted drug candidates through palladium-catalyzed cross-coupling reactions. Researchers utilize this chemical in structure-activity relationship studies for CNS-active compounds and antimicrobial agents.

Safety and Hazards

GHS Hazard Statements

• H302 (83.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (83.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (83.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (83.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.