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Atomfair N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine C14H7ClF2N4O2

Description N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine (CAS No. 162012-67-1) is a high-purity quinazoline derivative designed for advanced research applications. This compound features a molecular formula of C14H7ClF2N4O2and a molecular weight of 336.68 g/mol, with a unique nitro-fluoro substitution pattern that enhances its reactivity and binding affinity. Its structural complexity makes it an ideal candidate for pharmaceutical development, particularly in kinase inhibition studies and targeted cancer therapies. The product is rigorously tested for purity (??95% by HPLC) and stability, ensuring reliable performance in sensitive assays. Available in milligram to gram quantities, it is supplied in amber vials under inert atmosphere to prevent degradation.

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Description

Description

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine (CAS No. 162012-67-1) is a high-purity quinazoline derivative designed for advanced research applications. This compound features a molecular formula of C14H7ClF2N4O2 and a molecular weight of 336.68 g/mol, with a unique nitro-fluoro substitution pattern that enhances its reactivity and binding affinity. Its structural complexity makes it an ideal candidate for pharmaceutical development, particularly in kinase inhibition studies and targeted cancer therapies. The product is rigorously tested for purity (??95% by HPLC) and stability, ensuring reliable performance in sensitive assays. Available in milligram to gram quantities, it is supplied in amber vials under inert atmosphere to prevent degradation.

  • CAS No: 162012-67-1
  • Molecular Formula: C14H7ClF2N4O2
  • Molecular Weight: 336.68
  • Exact Mass: 336.0225595
  • Monoisotopic Mass: 336.0225595
  • IUPAC Name: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
  • SMILES: C1=CC(=C(C=C1NC2=NC=NC3=CC(=C(C=C32)[N+](=O)[O-])F)Cl)F
  • Synonyms: 162012-67-1, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine, DTXSID60442902, DTXCID60393723, 808-276-1

Application

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine is primarily utilized in medicinal chemistry as a key intermediate for synthesizing EGFR (Epidermal Growth Factor Receptor) inhibitors. Researchers employ this compound to investigate structure-activity relationships in tyrosine kinase inhibition, particularly for non-small cell lung cancer (NSCLC) therapeutics. Its nitro group allows for further functionalization via reduction or nucleophilic substitution, enabling diversification of quinazoline-based drug candidates.

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