Description

N-(2-(p-bromophenoxy)ethyl)pyrrolidine (CAS No. 1081-73-8) is a high-purity organic compound with the molecular formula C₁₂H₁₆BrNO. This specialized chemical features a pyrrolidine moiety linked to a 4-bromophenoxyethyl group, making it a valuable intermediate in pharmaceutical and agrochemical research. Its IUPAC name, 1-[2-(4-bromophenoxy)ethyl]pyrrolidine, reflects its precise molecular structure. This compound is supplied as a crystalline solid or solution, with rigorous QC testing to ensure >98% purity (HPLC). Ideal for use in Suzuki couplings, nucleophilic substitutions, and as a ligand precursor. Packaged under inert gas in amber glass vials to ensure stability. SDS and analytical data (GC/MS, NMR) available upon request.

Properties

• CAS Number: 1081-73-8
• Complexity: 174
• IUPAC Name: 1-[2-(4-bromophenoxy)ethyl]pyrrolidine
• InChI: InChI=1S/C12H16BrNO/c13-11-3-5-12(6-4-11)15-10-9-14-7-1-2-8-14/h3-6H,1-2,7-10H2
• InChI Key: YDWKSSWZGXRQET-UHFFFAOYSA-N
• Exact Mass: 269.04153
• Molecular Formula: C12H16BrNO
• Molecular Weight: 270.17
• SMILES: C1CCN(C1)CCOC2=CC=C(C=C2)Br
• Topological: 12.5
• Monoisotopic Mass: 269.04153
• Synonyms: 1081-73-8, 1-(2-(4-bromophenoxy)ethyl)pyrrolidine, 1-[2-(4-Bromophenoxy)ethyl]pyrrolidine, N-(2-(p-Bromophenoxy)ethyl)pyrrolidine, EINECS 214-100-9, YDWKSSWZGXRQET-UHFFFAOYSA-, DTXSID70148408, DTXCID2070899, 214-100-9, inchi=1/c12h16brno/c13-11-3-5-12(6-4-11)15-10-9-14-7-1-2-8-14/h3-6h,1-2,7-10h2, n-[2-(4-bromophenoxy)ethyl]pyrrolidine, 4-[2-Pyrrolidinoethoxy]phenyl bromide, Pyrrolidine, 1-[2-(4-bromophenoxy)ethyl]-, 1-[2-(4-bromophenoxy)ethyl]-pyrrolidine, 1-bromo-4-(2-pyrrolidinylethoxy)benzene, 1-(2-(4-bromophenoxyl)ethyl)pyrrolidine, 1-[2-(4-bromophenoxyl)ethyl]pyrrolidine, CBMicro_021930, 1-[2-(4-bromo-phenoxy)-ethyl]-pyrrolidine, MFCD00003180, 4-[2-N,N-Pyrrolidinoethoxy]phenyl bromide, Oprea1_609515, SCHEMBL229697, SCHEMBL21054227, CHEBI:151118, CCG-9149, SBB057753, AKOS005166878, AB00296, AC-6417, 1-(2-(p-Bromophenoxy)ethyl)pyrrolidine, 1-[2-(4-bromophenoxy)-ethyl]pyrrolidine, AS-54402, 1-[2-(4-bromophenoxyl)ethyl]-pyrrolidine, BIM-0021871.P001, 1-[2-(4-bromophenoxy)-ethyl] pyrrolidine, 1-[2-(4-bromophenoxy)-ethyl]-pyrrolidine, 1-[2-(4-Bromophenoxy)ethyl]pyrrolidine #, DB-015666, CS-0006699, NS00023494, Pyrrolidine, 1-[2-(p-bromophenoxy)ethyl]-, ST50319771, 1-[2-(4-Bromophenoxy)ethyl]pyrrolidine, 95%, P59960, 1-{2-(4-Bromophenoxy)ethyl)pyrrolidine; 4-[2-Pyrrolidinoethoxy]phenyl bromide

Application

N-(2-(p-bromophenoxy)ethyl)pyrrolidine serves as a key building block in medicinal chemistry for developing dopamine receptor ligands. Researchers utilize this compound in palladium-catalyzed cross-coupling reactions to create novel heterocyclic systems. Its bromophenoxy group makes it particularly useful in structure-activity relationship (SAR) studies for CNS-targeting pharmaceuticals. The compound has shown utility in the synthesis of potential antipsychotic agents through reductive amination pathways.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.