Description

N-(2-Fluorophenyl)acetamide (CAS No. 399-31-5) is a high-purity fluorinated organic compound with the molecular formula C₈H₈FNO. This white to off-white crystalline powder is widely utilized in pharmaceutical research, agrochemical synthesis, and material science due to its unique fluorinated aromatic structure. With a molecular weight of 153.15 g/mol, it exhibits excellent stability under standard laboratory conditions and is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). Our product is rigorously tested to meet >98% purity standards (HPLC) and is supplied with comprehensive analytical documentation including ¹H NMR, ¹³C NMR, and MS spectra. Ideal for use as a building block in medicinal chemistry, this compound serves as a key intermediate in the development of novel fluorinated drug candidates and specialty chemicals. Packaged under inert atmosphere in amber glass vials to ensure long-term stability.

Properties

• CAS Number: 399-31-5
• Complexity: 149
• IUPAC Name: N-(2-fluorophenyl)acetamide
• InChI: InChI=1S/C8H8FNO/c1-6(11)10-8-5-3-2-4-7(8)9/h2-5H,1H3,(H,10,11)
• InChI Key: AUZPZBPZWHEIDY-UHFFFAOYSA-N
• Exact Mass: 153.058992041
• Molecular Formula: C8H8FNO
• Molecular Weight: 153.15
• SMILES: CC(=O)NC1=CC=CC=C1F
• Topological: 29.1
• Monoisotopic Mass: 153.058992041
• Synonyms: N-(2-Fluorophenyl)acetamide, EINECS 206-916-9, DTXSID40192938, NSC 51783, DTXCID80115429, 206-916-9, 2′-Fluoroacetanilide, 399-31-5, Acetamide, N-(2-fluorophenyl)-, MFCD00000315, 2-FLUOROPHENYL ACETAMIDE, a-fluoroacetanilide, NSC51783, Maybridge1_008728, N-Acetyl-2-fluoroaniline, 1-Acetamido-2-fluorobenzene, CHEMBL121805, SCHEMBL1430533, SCHEMBL2306443, SCHEMBL2489381, SCHEMBL5475468, SCHEMBL5475470, SCHEMBL7399776, N-(2-Fluorophenyl)acetamide #, HMS566E16, NSC-51783, SBB055359, AKOS002960125, AB11465, FF70963, MS-0024, SB75961, BP-11831, ST094898, SY048734, CS-0153964, F0524, NS00043686, EN300-78574, AE-562/40169431, Z28290266

N-(2-Fluorophenyl)acetamide serves as a versatile intermediate in pharmaceutical synthesis, particularly for developing fluorinated aniline derivatives with enhanced bioavailability. Researchers employ this compound in Suzuki coupling reactions to create biaryl structures for kinase inhibitor development. Its electron-withdrawing fluorine moiety makes it valuable for studying structure-activity relationships in medicinal chemistry programs targeting CNS disorders.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.