Description
N-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine (CAS: 931398-72-0) is a high-purity biochemical compound designed for advanced research applications. This quinoline derivative, with the molecular formula C19H16N2O5, is widely recognized in scientific literature as IOX2, a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH). Its unique structure enables precise modulation of hypoxia-related pathways, making it invaluable for studies in cellular metabolism, angiogenesis, and ischemic disease research. Available in ≥98% purity (HPLC), this product undergoes rigorous QC testing to ensure consistency and performance. Suitable for in vitro and in vivo studies, it is provided as a lyophilized powder with detailed analytical data (MS, NMR). Store at -20°C protected from light.
Properties
- CAS Number: 931398-72-0
- Complexity: 609
- IUPAC Name: 2-[(1-benzyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]acetic acid
- InChI: InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
- InChI Key: CAOSCCRYLYQBES-UHFFFAOYSA-N
- Exact Mass: 352.10592162
- Molecular Formula: C19H16N2O5
- Molecular Weight: 352.3
- SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
- Topological: 107
- Monoisotopic Mass: 352.10592162
- Synonyms: 931398-72-0, DTXSID70715755, N-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine, DTXCID20666501, IOX2, IOX 2, 2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid, 2-[(1-benzyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]acetic acid, N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine, CHEMBL3186774, N-[(1-BENZYL-4-HYDROXY-2-OXO-1,2-DIHYDRO-3-QUINOLINYL)CARBONYL]GLYCIN, IOX2 (May Contain ~10% Inorganics), IOX2 sodium salt, MFCD22580424, IOX2?, MLS006011057, GTPL8229, SCHEMBL8244419, CHEBI:95087, EX-A099, HMS3426G15, HMS3651B12, BCP06141, BCP25372, BDBM50510124, NSC794199, s2919, IOX2, >=98% (HPLC), AKOS024458165, GSK-1002083-A, CCG-268051, CS-0988, FB40518, NSC-794199, SB19301, NCGC00344625-02, NCGC00344625-13, AC-32087, BS-17896, DA-40407, HY-15468, SMR004702849, SW219205-1, BRD-K98251413-001-04-0, Q27078086, sodium (1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycinate, N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine
IOX2 is extensively used in hypoxia research to stabilize HIF-1α by inhibiting prolyl hydroxylase domain (PHD) enzymes. Applications include studying oxygen-sensing mechanisms, erythropoiesis, and tumor microenvironment adaptation. It also serves as a tool compound for investigating ischemic preconditioning and metabolic reprogramming in cancer cells.
Safety and Hazards
GHS Hazard Statements
- H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
Precautionary Statements
- P264, P270, P301+P316, P321, P330, P405, and P501
Hazard Classes and Categories
- Acute Tox. 3 (100%)
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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.


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