Description

Description

Methyl Trifluoroacetate (CAS No. 431-47-0) is a high-purity fluorinated ester with the molecular formula C₃H₃F₃O₂, also known by its IUPAC name methyl 2,2,2-trifluoroacetate. This colorless, volatile liquid is characterized by its strong ester-like odor and exceptional reactivity as a trifluoromethylating agent. With a boiling point of approximately 40-43??C, it exhibits excellent solvency properties for organic synthesis applications. Our product is rigorously tested to meet ??98% purity standards (GC analysis), with controlled water content (<0.1%) and acidity to ensure optimal performance in sensitive reactions. Packaged under inert gas in amber glass bottles or specialized fluoropolymer-lined containers to prevent moisture absorption and decomposition.

Key applications include: nucleophilic trifluoromethylation, peptide synthesis (as a protecting group reagent), and as a precursor for pharmaceuticals and agrochemicals. Compatible with anhydrous reaction conditions and commonly used in conjunction with organometallic catalysts. Material should be stored at 2-8??C in a well-ventilated area away from strong bases and oxidizers.

Application

Methyl trifluoroacetate serves as a versatile building block in pharmaceutical synthesis, particularly for introducing trifluoromethyl groups into drug molecules to enhance metabolic stability. It’s widely employed as a mild esterification agent for protecting carboxylic acids during peptide synthesis. The compound also finds use in organic synthesis as a precursor for trifluoroacetyl derivatives and in the manufacture of specialty fluoropolymers. Its volatility makes it suitable for vapor-phase deposition processes in material science applications.

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