Description

Methyl Fluorosulfonate (CH₃FO₃S) is a highly reactive organosulfur compound with the CAS number 421-20-5. Also known as fluorosulfonyloxymethane by IUPAC nomenclature, this chemical is a potent alkylating agent and fluorosulfonating reagent. Its molecular structure consists of a methyl group bonded to a fluorosulfonate moiety, making it a valuable intermediate in organic synthesis and industrial applications. Methyl fluorosulfonate is widely recognized for its use in methylation reactions, where it efficiently transfers the methyl group to nucleophiles. Due to its extreme reactivity and toxicity, it must be handled with stringent safety protocols, including the use of personal protective equipment (PPE) and fume hoods. This product is supplied in high-purity form, ensuring consistency for research and specialized chemical processes. Synonyms include Methyl fluorosulfate and ‘Magic methyl.’

Properties

• CAS Number: 421-20-5
• Complexity: 107
• IUPAC Name: fluorosulfonyloxymethane
• InChI: InChI=1S/CH3FO3S/c1-5-6(2,3)4/h1H3
• InChI Key: MBXNQZHITVCSLJ-UHFFFAOYSA-N
• Exact Mass: 113.97869329
• Molecular Formula: CH3FO3S
• Molecular Weight: 114.10
• SMILES: COS(=O)(=O)F
• Topological: 51.8
• Monoisotopic Mass: 113.97869329
• Physical Description: Colorless liquid with an ethereal odor; Cloudy colorless or yellow liquid;
• Synonyms: METHYL FLUOROSULFONATE, 421-20-5, Methyl fluorosulfate, Magic methyl, Methyl fluorosulphate, Methyl fluosulfonate, Fluorosulfuric acid, methyl ester, Fluorosulfuric Acid Methyl Ester, CCRIS 1135, HSDB 4375, EINECS 207-004-3, Sulfuryl fluoride methyl ester, BRN 1098714, methyl fluoridosulfate, N015VFJ94Z, DTXSID8073180, METHYL FLUOROSULFONATE [MI], METHYL FLUOROSULFONATE [HSDB], fluoridosulfuric acid (HSO_3_), methyl ester, DTXCID1040031, 207-004-3, inchi=1/ch3fo3s/c1-5-6(2,3)4/h1h, methylfluorosulfonate, fluorosulfonyloxymethane, Methyl fluorosulphonate, methyl sulfurofluoridate, UNII-N015VFJ94Z, SCHEMBL526480, Fluorosulfonic Acid Methyl Ester, AKOS006221871, AS-80940, F0238, NS00031101, E78840, Q751430, Methyl Fluorosulfonate (stabilized with KF) [for Esterification]

Application

Methyl fluorosulfonate is primarily used as a powerful methylating agent in organic synthesis, enabling the introduction of methyl groups into various substrates. It finds application in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals where selective methylation is required. Due to its reactivity, it is also employed in laboratories for derivatization and functionalization of complex molecules. Additionally, it serves as a fluorosulfonating reagent in the synthesis of sulfonate esters. Strict handling procedures are necessary due to its hazardous nature.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P320, P321, P330, P332+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Acute Tox. 3 (100%)
• Acute Tox. 3 (100%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (100%)
• Acute Tox. 1 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.