Description

Methyl chlorodifluoroacetate (CAS No. 1514-87-0) is a high-purity fluorinated ester with the molecular formula C₃H₃ClF₂O₂, widely used in organic synthesis and pharmaceutical applications. This compound, also known as methyl 2-chloro-2,2-difluoroacetate, is a versatile reagent for introducing difluoromethyl and chloroacetate functionalities into target molecules. Its excellent reactivity makes it a valuable intermediate for the preparation of fluorinated compounds, agrochemicals, and active pharmaceutical ingredients (APIs).

Our product is rigorously tested to ensure superior quality, with ≥98% purity (GC) and low levels of impurities. It is supplied in sealed, moisture-resistant packaging to maintain stability and shelf life. Ideal for researchers and industrial chemists, this compound is a critical building block in the development of advanced materials and bioactive molecules.

Properties

• CAS Number: 1514-87-0
• Complexity: 103
• IUPAC Name: methyl 2-chloro-2,2-difluoro-acetate
• InChI: InChI=1S/C3H3ClF2O2/c1-8-2(7)3(4,5)6/h1H3
• InChI Key: AWUPLMYXZJKHEG-UHFFFAOYSA-N
• Exact Mass: 143.9789634
• Molecular Formula: C3H3ClF2O2
• Molecular Weight: 144.50
• SMILES: COC(=O)C(F)(F)Cl
• Topological: 26.3
• Monoisotopic Mass: 143.9789634
• Synonyms: Methyl chlorodifluoroacetate, 1514-87-0, Methyl 2-chloro-2,2-difluoroacetate, Acetic acid, 2-chloro-2,2-difluoro-, methyl ester, EINECS 216-154-9, DTXSID5061742, AWUPLMYXZJKHEG-UHFFFAOYSA-, DTXCID8034900, 216-154-9, awuplmyxzjkheg-uhfffaoysa-n, inchi=1/c3h3clf2o2/c1-8-2(7)3(4,5)6/h1h3, Chlorodifluoroacetic Acid Methyl Ester, methyl chloro(difluoro)acetate, Acetic acid, chlorodifluoro-, methyl ester, MFCD00000775, ClCF2COOMe, ClCF2CO2Me, methyl chlorodifluroacetate, KU7C5W6LVK, SCHEMBL132957, Methyl chlorodifluoroacetate, 99%, BCP24416, methyl-2-chloro-2,2-difluoroacetate, STL414617, AKOS009031549, chlorodifluoro acetic acid methyl ester, SB40724, chloro-difluoro-acetic acid methyl ester, DB-043097, CS-0017970, NS00024941, EN300-20460, 2-chloro-2,2-difluoroacetic acid methyl ester, F11158, Acetic acid,2-chloro-2,2-difluoro-, methyl ester

Application

Methyl chlorodifluoroacetate is widely employed as a fluorinating agent in organic synthesis, particularly in the preparation of difluoromethylated compounds. It serves as a key intermediate in pharmaceutical research for modifying drug candidates to enhance metabolic stability and bioavailability. Additionally, this reagent is utilized in agrochemical production for synthesizing fluorinated pesticides and herbicides with improved efficacy.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H314 (98%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Skin Corr. 1B (98%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.