Description

Methyl 6-chloropyridazine-3-carboxylate (CAS No. 65202-50-8) is a high-purity heterocyclic compound with the molecular formula C₆H₅ClN₂O₂. This specialized chemical is widely utilized in pharmaceutical and agrochemical research as a key intermediate for synthesizing biologically active molecules. The compound features a pyridazine core substituted with a chlorine atom at the 6-position and a methyl ester group at the 3-position, offering versatile reactivity for further derivatization. Our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied as a crystalline solid with excellent batch-to-batch consistency. Proper storage at 2-8°C under inert atmosphere is recommended to maintain stability.

Properties

• CAS Number: 65202-50-8
• Complexity: 154
• IUPAC Name: methyl 6-chloropyridazine-3-carboxylate
• InChI: InChI=1S/C6H5ClN2O2/c1-11-6(10)4-2-3-5(7)9-8-4/h2-3H,1H3
• InChI Key: FPKXYXKLOWAIOX-UHFFFAOYSA-N
• Exact Mass: 172.0039551
• Molecular Formula: C6H5ClN2O2
• Molecular Weight: 172.57
• SMILES: COC(=O)C1=NN=C(C=C1)Cl
• Topological: 52.1
• Monoisotopic Mass: 172.0039551
• Synonyms: methyl 6-chloropyridazine-3-carboxylate, 65202-50-8, DTXSID10495387, DTXCID10446197, 691-623-2, 6-chloropyridazine-3-carboxylic acid methyl ester, methyl 3-chloropyridazine-6-carboxylate, MFCD08694876, 6-chloro-pyridazine-3-carboxylic acid methyl ester, 3-Pyridazinecarboxylic acid, 6-chloro-, methyl ester, SCHEMBL474101, FPKXYXKLOWAIOX-UHFFFAOYSA-N, SBB053957, AKOS000265217, methyl 6-chloropyridazin-3-carboxylate, CS-W005175, PB18925, PS-4664, methyl 6-chloro-3-pyridazinecarboxylate, methyl-6-chloropyridazine-3-carboxylate, methyl 6-chloro-pyridazine-3-carboxylate, Methyl-6-chloro-pyridazine-3-carboxylate, AC-23059, SY007129, DB-013459, EN300-37485, Z381058224

Application

Methyl 6-chloropyridazine-3-carboxylate serves as a crucial building block in medicinal chemistry for the development of kinase inhibitors and other therapeutic agents. Researchers employ this compound in palladium-catalyzed cross-coupling reactions to create diverse pyridazine derivatives. The chloropyridazine moiety also finds application in the synthesis of agricultural chemicals, particularly as a precursor for herbicides and pesticides. Its ester functionality allows for straightforward conversion to carboxylic acids or amides, enabling structure-activity relationship studies.

Safety and Hazards

GHS Hazard Statements

• H302 (60%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (20%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (20%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (60%)
• Acute Tox. 4 (20%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (20%)
• STOT SE 3 (80%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.