Description

Methyl 2-Fluoro-2-methylpropionate (CAS: 338-76-1) is a high-purity fluorinated ester compound with the molecular formula C₅H₉FO₂. This specialty chemical is widely utilized in pharmaceutical synthesis, agrochemical research, and advanced material development due to its unique fluorinated structure. Its clear, colorless liquid form and high chemical stability make it an excellent candidate for precision applications in fine chemical manufacturing. With a boiling point of approximately 108-110°C and a density of ~1.01 g/mL at 25°C, this reagent offers exceptional solubility in common organic solvents. Our product undergoes rigorous QC testing via GC-MS and NMR to ensure >98% purity, meeting the stringent requirements of research and industrial applications.

Properties

• CAS Number: 338-76-1
• Complexity: 98.6
• IUPAC Name: methyl 2-fluoro-2-methyl-propanoate
• InChI: InChI=1S/C5H9FO2/c1-5(2,6)4(7)8-3/h1-3H3
• InChI Key: OEGBOFOVYSOERL-UHFFFAOYSA-N
• Exact Mass: 120.05865769
• Molecular Formula: C5H9FO2
• Molecular Weight: 120.12
• SMILES: CC(C)(C(=O)OC)F
• Topological: 26.3
• Monoisotopic Mass: 120.05865769
• Synonyms: METHYL 2-FLUORO-2-METHYLPROPIONATE, METHYL 2-FLUOROISOBUTYRATE, 830-079-4, Methyl 2-fluoro-2-methylpropanoate, 338-76-1, MFCD03265444, 2-fluoro-2-methylpropanoic acid methyl ester, Propanoic acid, 2-fluoro-2-methyl-, methyl ester, SCHEMBL226311, DTXSID40430706, Methyl2-fluoro-2-methylpropanoate, AKOS005063664, AB13921, DS-1916, methyl 2-fluoranyl-2-methyl-propanoate, SY004591, CS-0017916, M2827, 2-Fluoro-2-methylpropionic Acid Methyl Ester, EN300-226187, A821976, propanoic acid,2-fluoro-2-methyl-, methyl ester;methyl 2-fluoro-2-methylpropanoate;

Methyl 2-Fluoro-2-methylpropionate serves as a key fluorinated building block in nucleoside analog synthesis for antiviral drug development. It’s employed as a chiral auxiliary in asymmetric synthesis and as a precursor for fluorine-containing polymers with enhanced thermal stability. Researchers value its reactivity in palladium-catalyzed cross-coupling reactions for pharmaceutical intermediates. The compound also finds use in modifying bioactive molecules to enhance metabolic stability through fluorine incorporation.

Safety and Hazards

GHS Hazard Statements

• H225 (50%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H226 (50%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (50%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (50%)
• Flam. Liq. 3 (50%)
• Skin Corr. 1B (50%)
• Eye Dam. 1 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.