Description

Methyl (2-chlorophenyl)acetate (CAS No. 57486-68-7) is a high-purity organic ester compound widely utilized in pharmaceutical synthesis, agrochemical development, and specialty chemical manufacturing. With the molecular formula C₉H₉ClO₂, this versatile reagent serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs), fragrances, and fine chemicals. Its clear to pale-yellow liquid form and distinct aromatic ester profile make it ideal for precision applications requiring controlled reactivity.

Packaged under inert conditions to ensure stability, our product undergoes rigorous QC testing (HPLC, GC, NMR) to guarantee ≥98% purity, meeting stringent industry standards for research and production. Available in scalable quantities from grams to multi-kilogram batches, it is compatible with Schlenk-line techniques and inert-atmosphere handling. Store in a cool, dry environment away from strong oxidizers.

Properties

• CAS Number: 57486-68-7
• Complexity: 159
• IUPAC Name: methyl 2-(2-chlorophenyl)acetate
• InChI: InChI=1S/C9H9ClO2/c1-12-9(11)6-7-4-2-3-5-8(7)10/h2-5H,6H2,1H3
• InChI Key: KHBWTRFWQROKJZ-UHFFFAOYSA-N
• Exact Mass: 184.0291072
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.62
• SMILES: COC(=O)CC1=CC=CC=C1Cl
• Topological: 26.3
• Monoisotopic Mass: 184.0291072
• Synonyms: 57486-68-7, Methyl (2-chlorophenyl)acetate, benzeneacetic acid, 2-chloro-, methyl ester, EINECS 260-764-8, DTXSID30206098, DTXCID30128589, 260-764-8, inchi=1/c9h9clo2/c1-12-9(11)6-7-4-2-3-5-8(7)10/h2-5h,6h2,1h, Methyl 2-chlorophenylacetate, methyl 2-(2-chlorophenyl)acetate, 2-Chlorophenylacetic acid methylester, MFCD00137445, 2-Chlorobenzeneacetic acid methyl ester, (2-Chlorophenyl)acetic Acid Methyl Ester, Methyl2-Chlorophenylacetate, methyl(2-chlorophenyl)acetate, 2-chlorophenylacetic acid methyl ester, methyl o-chlorophenylacetate, SCHEMBL872658, SCHEMBL7567436, SCHEMBL15514819, AKOS008910004, methyl 2-(2,6-chlorophenyl) acetate, SY021282, (2-chlorophenyl)-acetic acid methyl ester, (2-Chloro-phenyl)-acetic acid methyl ester, DB-053058, C1740, CS-0030578, NS00033735, ST50406081, EN300-64539, Z24820310

Methyl (2-chlorophenyl)acetate is primarily employed as a key building block in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other chlorinated aromatic pharmaceuticals. It also finds use in crop protection chemical development, particularly for herbicides targeting chlorophenoxy acid derivatives. Researchers value its reactivity in esterification and transesterification reactions under mild conditions.

Safety and Hazards

GHS Hazard Statements

• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2A (66.7%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.