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Atomfair Methyl 2-bromothiophene-3-carboxylate C6H5BrO2S CAS 76360-43-5

Methyl 2-bromothiophene-3-carboxylate (CAS No. 76360-43-5) is a high-purity brominated thiophene derivative with the molecular formula C6H5BrO2S . This compound is a valuable synthetic intermediate in organic chemistry and pharmaceutical research, featuring a reactive bromine substituent at the 2-position and an ester group at the 3-position of the thiophene ring. Its well-defined structure (IUPAC name: methyl 2-bromothiophene-3-carboxylate) makes it ideal for cross-coupling reactions, such as Suzuki or Stille couplings, as well as nucleophilic substitutions. Available in >98% purity (GC), it is supplied in sealed packaging under inert gas to ensure stability. Suitable for use in medicinal chemistry, material science, and agrochemical…

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Description

Methyl 2-bromothiophene-3-carboxylate (CAS No. 76360-43-5) is a high-purity brominated thiophene derivative with the molecular formula C6H5BrO2S. This compound is a valuable synthetic intermediate in organic chemistry and pharmaceutical research, featuring a reactive bromine substituent at the 2-position and an ester group at the 3-position of the thiophene ring. Its well-defined structure (IUPAC name: methyl 2-bromothiophene-3-carboxylate) makes it ideal for cross-coupling reactions, such as Suzuki or Stille couplings, as well as nucleophilic substitutions. Available in >98% purity (GC), it is supplied in sealed packaging under inert gas to ensure stability. Suitable for use in medicinal chemistry, material science, and agrochemical synthesis. Store in a cool, dry place away from light.

Properties

  • CAS Number: 76360-43-5
  • Complexity: 140
  • IUPAC Name: methyl 2-bromothiophene-3-carboxylate
  • InChI: InChI=1S/C6H5BrO2S/c1-9-6(8)4-2-3-10-5(4)7/h2-3H,1H3
  • InChI Key: ADKGOXMEPLSPNN-UHFFFAOYSA-N
  • Exact Mass: 219.91936
  • Molecular Formula: C6H5BrO2S
  • Molecular Weight: 221.07
  • SMILES: COC(=O)C1=C(SC=C1)Br
  • Topological: 54.5
  • Monoisotopic Mass: 219.91936
  • Synonyms: Methyl 2-bromothiophene-3-carboxylate, 76360-43-5, DTXSID40693354, DTXCID80644103, MFCD16657906, 2-Bromo-thiophene-3-carboxylic acid methyl ester, Methyl-2-bromothiophene-3-carboxylate, 2-bromothiophene-3-carboxylic acid methyl ester, 3-Thiophenecarboxylic acid, 2-bromo-, methyl ester, SCHEMBL1450859, SCHEMBL29189393, ADKGOXMEPLSPNN-UHFFFAOYSA-N, Methyl2-bromothiophene-3-carboxylate, AKOS005266419, CS-W018777, methyl 2-bromo-3-thiophene carboxylate, AS-20089, SY113397, DB-075110, F10378

Application

Methyl 2-bromothiophene-3-carboxylate is widely used as a key building block in the synthesis of thiophene-based pharmaceuticals and functional materials. It serves as a precursor for palladium-catalyzed cross-coupling reactions to construct complex heterocyclic systems. Researchers also employ it in the development of organic semiconductors and conductive polymers due to its electron-rich thiophene core. Its bromine moiety allows further functionalization for targeted drug discovery projects.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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