Description

Methyl 2-amino-5-fluorobenzoate (CAS No. 319-24-4) is a high-purity fluorinated aromatic ester with the molecular formula C₈H₈FNO₂. This compound is widely utilized in organic synthesis, pharmaceutical research, and material science due to its reactive amino and ester functional groups. Its IUPAC name, methyl 2-amino-5-fluorobenzoate, reflects its precise chemical structure, featuring a fluorine substituent at the 5-position and an amino group at the 2-position of the benzoate ring. This product is supplied as a fine crystalline powder or solid with ≥98% purity (HPLC), ensuring optimal performance in sensitive applications. Suitable for use as an intermediate in drug discovery, agrochemical development, and specialty chemical manufacturing, it is packaged under inert conditions to maintain stability and shelf life. Store in a cool, dry place away from light and moisture.

Properties

• CAS Number: 319-24-4
• Complexity: 174
• IUPAC Name: methyl 2-amino-5-fluoro-benzoate
• InChI: InChI=1S/C8H8FNO2/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4H,10H2,1H3
• InChI Key: PUDDYSBKCDKATP-UHFFFAOYSA-N
• Exact Mass: 169.05390666
• Molecular Formula: C8H8FNO2
• Molecular Weight: 169.15
• SMILES: COC(=O)C1=C(C=CC(=C1)F)N
• Topological: 52.3
• Monoisotopic Mass: 169.05390666
• Synonyms: Methyl 2-amino-5-fluorobenzoate, 319-24-4, DTXSID80382639, EC 608-681-1, DTXCID60333664, 608-681-1, 2-Amino-5-fluorobenzoic acid methyl ester, METHYL 5-FLUOROANTHRANILATE, BENZOIC ACID, 2-AMINO-5-FLUORO-, METHYL ESTER, MFCD03791308, methyl2-amino-5-fluorobenzoate, methyl 2-amino-5-fluoro-benzoate, 4-Fluoro-2-(methoxycarbonyl)aniline, SCHEMBL165608, methyl-2-amino-5-fluorobenzoate, PUDDYSBKCDKATP-UHFFFAOYSA-N, SBB053778, 5-Fluoroanthranilic Acid Methyl Ester, AKOS005255207, AC-3881, CS-W007783, PS-8717, BP-21337, SY009285, 2-Amino-5-fluoro-benzoic acid methyl ester, DB-048128, M2899, NS00008132, ST50408511, EN300-42149, Benzoic acid, 2-?amino-?5-?fluoro-?, methyl ester, Z54593024

Application

Methyl 2-amino-5-fluorobenzoate serves as a versatile building block in pharmaceutical synthesis, particularly for the development of fluorinated active pharmaceutical ingredients (APIs). It is employed in the preparation of heterocyclic compounds and as a precursor for antineoplastic and antimicrobial agents. Researchers also utilize this compound in material science for designing fluorinated polymers with enhanced thermal and chemical resistance. Its reactivity makes it valuable in cross-coupling reactions and as a substrate for further functionalization.

Safety and Hazards

GHS Hazard Statements

• H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (40%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (40%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (10%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (30%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (70%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (20%)
• Skin Irrit. 2 (40%)
• Eye Irrit. 2A (40%)
• STOT SE 3 (30%)
• Aquatic Chronic 3 (70%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.