Description

Methoxytrimethylsilane (CAS No. 1825-61-2) is a highly versatile organosilicon compound with the molecular formula C₄H₁₂OSi. This clear, volatile liquid is widely used as a silylating agent and protective group reagent in organic synthesis and material science. With its IUPAC name methoxy(trimethyl)silane, this compound features a reactive methoxy group bound to a trimethylsilyl moiety, making it particularly valuable for introducing silyl protecting groups in sensitive chemical transformations.

Our high-purity grade (typically >98%) is rigorously tested by GC and NMR to ensure consistency for research applications. The compound’s low boiling point (55-57°C) and moisture sensitivity require careful handling under inert atmosphere. Available in convenient packaging options from 100 mL to bulk quantities, with optional ampouling for air-sensitive applications.

Key applications include:

• Protection of hydroxyl groups in carbohydrate chemistry
• Precursor for silicon-containing thin films in CVD processes
• Surface modification of silica materials
• Intermediate in pharmaceutical synthesis

Properties

• CAS Number: 1825-61-2
• Complexity: 37.3
• IUPAC Name: methoxy(trimethyl)silane
• InChI: InChI=1S/C4H12OSi/c1-5-6(2,3)4/h1-4H3
• InChI Key: POPACFLNWGUDSR-UHFFFAOYSA-N
• Exact Mass: 104.065741536
• Molecular Formula: C4H12OSi
• Molecular Weight: 104.22
• SMILES: CO[Si](C)(C)C
• Topological: 9.2
• Monoisotopic Mass: 104.065741536
• Physical Description: Colorless liquid with a mild odor;
• Synonyms: METHOXYTRIMETHYLSILANE, Silane, methoxytrimethyl-, (CH3)3SiOCH3, Methanol, TMS derivative, EINECS 217-369-0, NSC 139858, DTXSID5062001, Silane, methoxytrimethyl, DTXCID7035804, 217-369-0, popacflnwgudsr-uhfffaoysa-n, un1993, 1825-61-2, Trimethylmethoxysilane, Methyl trimethylsilyl ether, methoxy(trimethyl)silane, trimethyl methoxysilane, 2M9U6DL2PM, NSC-139858, Methyl trimethylsilyl ether; NSC 139858; SS 2010; TSL 8111; Trimethylmethoxysilane, TMSOMe, MFCD00008344, NSC139858, methoxy trimethylsilane, methoxytrimethyl silane, UNII-2M9U6DL2PM, Methoxytrimethylsilane, 99%, Trimethylmethoxysilane(96%), SCHEMBL28152, SCHEMBL96721, SCHEMBL2971856, SCHEMBL11060351, SCHEMBL11890196, SCHEMBL15194065, TSL-8111, LS-510, AKOS005207156, SS-2010, LS-13026, DB-044467, M0688, NS00046427, D94568, Z-6013, EN300-7572994

Application

Methoxytrimethylsilane serves as an efficient silylating agent for protecting hydroxyl groups in complex organic syntheses, particularly in nucleoside and carbohydrate chemistry. In materials science, it functions as a precursor for chemical vapor deposition (CVD) of silicon oxide films and surface modification of silica nanoparticles. The compound’s volatility and reactivity make it valuable for creating hydrophobic surfaces in nanotechnology applications.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H319 (37.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P264+P265, P280, P303+P361+P353, P305+P351+P338, P337+P317, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Eye Irrit. 2 (37.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.