Description

m-Fluorotoluene (CAS No. 352-70-5) is a high-purity aromatic compound with the molecular formula C₇H₇F. This colorless to pale-yellow liquid is widely utilized in organic synthesis, pharmaceutical research, and material science due to its versatile reactivity as a fluorinated building block. Its stable structure, featuring a fluorine substituent at the meta position relative to the methyl group, makes it ideal for introducing fluorinated motifs into complex molecules. m-Fluorotoluene is rigorously tested to meet stringent quality standards, ensuring consistency in reactions such as nucleophilic substitutions, cross-coupling, and electrophilic aromatic substitutions. Packaged under inert conditions to preserve integrity, it is suitable for use in catalysis, agrochemical development, and fine chemical manufacturing. Handle with appropriate safety measures, including ventilation and personal protective equipment (PPE), due to its flammability.

Properties

• CAS Number: 352-70-5
• Complexity: 70.8
• IUPAC Name: 1-fluoro-3-methyl-benzene
• InChI: InChI=1S/C7H7F/c1-6-3-2-4-7(8)5-6/h2-5H,1H3
• InChI Key: BTQZKHUEUDPRST-UHFFFAOYSA-N
• Exact Mass: 110.053178385
• Molecular Formula: C7H7F
• Molecular Weight: 110.13
• SMILES: CC1=CC(=CC=C1)F
• Monoisotopic Mass: 110.053178385
• Physical Description: 3-fluorotoluene appears as a colorless liquid with an aromatic odor. Boiling point 239 °C. Flash point 63 °F. Density 0.991 g / cm3 — may float or sink in water.
• Boiling Point: 240.8 °F at 760 mmHg
• Melting Point: -125.9 °F
• Flash Point: 49 °F
• Density: 0.9986 at 68 °F – Less dense than water; will float
• Vapor Pressure: 42.39 mmHg
• Synonyms: 3-Fluorotoluene, 352-70-5, 1-Fluoro-3-methylbenzene, M-FLUOROTOLUENE, Benzene, 1-fluoro-3-methyl-, Toluene, m-fluoro-, 1-Methyl-3-fluorobenzene, F72W445DQ0, NSC 8860, NSC-8860, EINECS 206-524-8, M-FLUOROTOLUENE [MI], DTXSID2059855, EC 206-524-8, 3fluorotoluene, mTolyl fluoride, Toluene, mfluoro, 1Fluoro3methylbenzene, 1Methyl3fluorobenzene, M-TOLYL FLUORIDE, Benzene, 1fluoro3methyl, Toluene, mfluoro (8CI), Toluene, m-fluoro-(8CI), DTXCID5038961, 206-524-8, InChI=1/C7H7F/c1-6-3-2-4-7(8)5-6/h2-5H,1H, 1-Fluoro-3-methyl-benzene, 3-Fluorobenzyl radical, CHEMBL345698, 2599-73-7, UNII-F72W445DQ0, meta-Fluorotoluene, 3-Fluorotoluene, 99%, SCHEMBL11881, SCHEMBL26517, SCHEMBL96411, 1-fluoranyl-3-methyl-benzene, SCHEMBL150501, SCHEMBL160827, SCHEMBL161280, SCHEMBL262231, SCHEMBL1803542, SCHEMBL16465077, NSC8860, DTXSID001031339, BDBM50008564, MFCD00000339, SBB061650, STL301893, AKOS000119943, PS-11961, DB-023924, F0040, NS00005603, ST51047654, EN300-19503, m-Fluorotoluene [UN2388] [Flammable liquid], A822704, Q27277748, F0001-1021, Z104474044

m-Fluorotoluene serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its meta-substituted fluorine atom enhances electron-withdrawing properties, facilitating regioselective reactions in drug discovery. The compound is also employed in the production of liquid crystals, dyes, and polymers, where its fluorine moiety improves thermal and chemical stability. Researchers leverage its reactivity in palladium-catalyzed cross-coupling reactions to construct biaryl systems. Additionally, it finds use as a solvent or reagent in organofluorine chemistry.

Safety and Hazards

GHS Hazard Statements

• H225 (56%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H315 (48.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (48.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (52.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (56%)
• Skin Irrit. 2 (48.8%)
• Eye Irrit. 2 (48.8%)
• STOT SE 3 (52.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.