Description

L-Phenylalanine, phenylmethyl ester, hydrochloride (1:1) is a high-purity amino acid derivative widely utilized in peptide synthesis and biochemical research. This compound, with the molecular formula C₁₆H₁₈ClNO₂, is a protected form of L-Phenylalanine, featuring a benzyl ester group and hydrochloride salt for enhanced stability and solubility. It is an essential building block for solid-phase peptide synthesis (SPPS) and other organic transformations, offering excellent chiral purity (>99%) and compatibility with Fmoc/t-Boc strategies. The product is rigorously tested via HPLC, NMR, and mass spectrometry to ensure compliance with research-grade standards. Ideal for pharmaceutical development, enzymology studies, and proteomics applications.

Properties

• CAS Number: 2462-32-0
• Complexity: 268
• IUPAC Name: benzyl (2S)-2-amino-3-phenyl-propanoate;hydrochloride
• InChI: InChI=1S/C16H17NO2.ClH/c17-15(11-13-7-3-1-4-8-13)16(18)19-12-14-9-5-2-6-10-14;/h1-10,15H,11-12,17H2;1H/t15-;/m0./s1
• InChI Key: CEXFHIYDTRNBJD-RSAXXLAASA-N
• Exact Mass: 291.1026065
• Molecular Formula: C16H18ClNO2
• Molecular Weight: 291.77
• SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)OCC2=CC=CC=C2)N.Cl
• Topological: 52.3
• Monoisotopic Mass: 291.1026065
• Synonyms: L-Phenylalanine, phenylmethyl ester, hydrochloride (1:1), 2462-32-0, L-Phenylalanine benzyl ester hydrochloride, H-Phe-OBzl.HCl, L-Phe-OBZl.HCl, L-Phenylalanine benzyl ester (hydrochloride), MFCD00043249, H-PHE-OBZL HCL, L-Phenylalanine benzyl ester, HCl, benzyl (2S)-2-amino-3-phenylpropanoate;hydrochloride, L-PHENYLALANINE BENZYL ESTER HCL, phenylmethyl (2S)-2-amino-3-phenylpropanoate, chloride, CEXFHIYDTRNBJD-RSAXXLAASA-N, Phenylalanine, phenylmethyl ester, hydrochloride, SCHEMBL353729, benzyl phenylalaninate hydrochloride, L-Phenylalaninbenzylesterhydrochlorid, HY-79908A, SBB058269, benzyl l-phenylalaninate hydrochloride, AKOS015889857, AKOS015922770, CS-W020561, FP47572, AS-12209, PD196135, DB-029979, NS00081507, P1718, ST50320125, benzyl (2S)-2-amino-3-phenyl-propanoate hydrochloride, L-Phenylalanine benzyl ester hydrochloride, >=99.0% (AT)

This compound serves as a key intermediate in peptide synthesis, enabling the incorporation of L-Phenylalanine residues with a temporary benzyl ester protecting group. It is particularly valuable in Fmoc-based SPPS workflows due to its orthogonal deprotection properties. Researchers also employ it in enzyme substrate studies and as a chiral precursor for drug discovery. Its hydrochloride salt form ensures improved handling and solubility in polar solvents.

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.