Description

Imatinib amine (CAS No. 152460-10-1) is a high-purity pharmaceutical intermediate and key metabolite of Imatinib, a well-known tyrosine kinase inhibitor. With the molecular formula C₁₆H₁₅N₅ and IUPAC name 4-methyl-3-N-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine, this compound is essential for research in medicinal chemistry and drug development. Imatinib amine is rigorously tested for quality, ensuring ≥95% purity by HPLC, and is supplied as a lyophilized powder or in solution for precise experimental use. Ideal for researchers studying kinase inhibition pathways, metabolite profiling, and the synthesis of targeted cancer therapeutics. Store under inert conditions at -20°C to maintain stability.

Properties

• CAS Number: 152460-10-1
• Complexity: 324
• IUPAC Name: 4-methyl-N3-[4-(3-pyridyl)pyrimidin-2-yl]benzene-1,3-diamine
• InChI: InChI=1S/C16H15N5/c1-11-4-5-13(17)9-15(11)21-16-19-8-6-14(20-16)12-3-2-7-18-10-12/h2-10H,17H2,1H3,(H,19,20,21)
• InChI Key: QGAIPGVQJVGBIA-UHFFFAOYSA-N
• Exact Mass: 277.13274550
• Molecular Formula: C16H15N5
• Molecular Weight: 277.32
• SMILES: CC1=C(C=C(C=C1)N)NC2=NC=CC(=N2)C3=CN=CC=C3
• Topological: 76.7
• Monoisotopic Mass: 277.13274550
• Synonyms: 152460-10-1, Imatinib amine, JR9RZF7KDS, Imatinib amine [USP], 1,3-Benzenediamine, 4-methyl-N3-(4-(3-pyridinyl)-2-pyrimidinyl)-, 1,3-Benzenediamine, 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-, IMATINIB AMINE [USP IMPURITY], Imatinib amine (USP), 4-Methyl-N3-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine, 4-Methyl-N3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine, IMATINIB AMINE (USP IMPURITY), 442-110-5, 604-859-8, N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine, 2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine, 6-methyl-N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine, 4-Methyl-N3-[4-(3-Pyridinyl)-2-Pyrimidinyl]-1,3-Benzenediamine, MFCD09028125, N-(5-Amino-o-tolyl)-4-(3-pyridyl)-2-pyrimidinamine, CHEMBL278103, N-(5-Amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine, 4-methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline, 4-methyl-3-N-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine, 6-METHYL-N1-[4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL]BENZENE-1,3-DIAMINE, 4-Methyl-N*3*-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine, C16H15N5, Imatinib Impurity F, UNII-JR9RZF7KDS, SCHEMBL2392, DTXSID30433443, N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine, BCP22918, AC-619, BDBM50287097, AKOS015888614, AC-2147, CCG-310976, CS-W014568, DS-0284, FA15934, SB60556, 112GI007, SY046834, A2308, Imatinib Mesilate Imprity F [EP IMPURITY], NS00077786, VU0549314-1, EN300-7372570, F9995-0188, Z1741977607, n-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine, N-(5-Amino-2-methylphenyl)-4-(3-pridyl)-2-pyrimidineamine, N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine amine, 4-methyl-N~3~-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine, 4-methyl-N3-[4-(3-piridinyl)-2-pirimidinyl]-1,3-benzendiamine, 4-Methyl-N3-[4-(3-pyridyl)-2-pyrimidinyl]-1,3-phenylenediamine, 6-Methyl-N-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine, 6-Methyl-N1-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,2-diamine, 6-Methyl-N1-[4-(3-pyridyl)-2-pyrimidinyl]-1,3-benzenediamine, N-(5-amino-2-methyl phenyl)-4-(3-pyridinyl)2-pyrimidine-amine, N-(5-amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidine-amine, 4-Methyl-N~3~-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine, 4-Methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline;4-Methyl-N’-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine;N-(5-Amino-o-to lyl)-4-(3-pyridyl)-2-pyrimidinamine

Application

Imatinib amine serves as a critical reference standard in pharmacokinetic studies of Imatinib, aiding in metabolite identification and quantification. It is widely used in oncology research to investigate the mechanisms of tyrosine kinase inhibition and resistance. This compound also supports the development of analytical methods for therapeutic drug monitoring in clinical settings.

Safety and Hazards

GHS Hazard Statements

• H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (80%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (80%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501

Hazard Classes and Categories

• Skin Sens. 1 (100%)
• STOT RE 2 (100%)
• Aquatic Chronic 2 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.