Description

Hexafluoropropylene oxide (HFPO) (CAS 428-59-1) is a high-purity fluorinated epoxide with the molecular formula C₃F₆O and IUPAC name 2,2,3-trifluoro-3-(trifluoromethyl)oxirane. This specialized chemical is widely utilized in advanced fluoropolymer synthesis, surface modification, and as a precursor for perfluorinated ethers. Its unique perfluorinated structure provides exceptional thermal stability, chemical inertness, and low surface energy properties. Our HFPO is rigorously tested to meet the highest purity standards, making it ideal for demanding applications in semiconductor manufacturing, specialty lubricants, and pharmaceutical intermediates. Available in secure, corrosion-resistant packaging with detailed technical specifications and safety documentation.

Properties

• CAS Number: 428-59-1
• Complexity: 161
• IUPAC Name: 2,2,3-trifluoro-3-(trifluoromethyl)oxirane
• InChI: InChI=1S/C3F6O/c4-1(2(5,6)7)3(8,9)10-1
• InChI Key: PGFXOWRDDHCDTE-UHFFFAOYSA-N
• Exact Mass: 165.98533359
• Molecular Formula: C3F6O
• Molecular Weight: 166.02
• SMILES: C1(C(O1)(F)F)(C(F)(F)F)F
• Topological: 12.5
• Monoisotopic Mass: 165.98533359
• Physical Description: Hexafluoropropylene oxide is a colorless odorless gas. It is shipped as a liquefied gas under its vapor pressure. Contact with the liquid can cause frostbite. Its vapors are heavier than air. It can cause asphyxiation by the displacement of air. Exposure of the container to prolonged heat or fire may cause it to rupture violently and rocket.
• Boiling Point: -18 °F at 760 mmHg
• Melting Point: -200 °F
• Synonyms: Hexafluoropropylene oxide, TRIFLUORO(TRIFLUOROMETHYL)OXIRANE, Perfluoropropylene oxide, Perfluoro(methyloxirane), UNII-JPY12AP87N, Oxirane, 2,2,3-trifluoro-3-(trifluoromethyl)-, HSDB 5424, EINECS 207-050-4, 1,2-Epoxyhexafluoropropane, (Trifluoromethyl)trifluorooxirane, DTXSID6029177, EC 207-050-4, NA 1956, HFPO2 compound, GenX-Na, GenX potassium salt, GenX-K, perfluoropropene oxide, HFPO-TeA, HFPO-TrA, Hexafluoro1,2epoxypropane, C6HF11O3.H3N, DTXCID009177, Oxirane, trifluoro(trifluoromethyl), per-and polyfluoroalkyl ether acids, GenX perfluoro(2-propoxypropanoate), HEXAFLUOROPROPENE-1,2-OXIDE, hexafluoropropylene oxide tetramer acid, PFEA per-and polyfluoroalkyl ether acids, Propane, 1,2epoxy1,1,2,3,3,3hexafluoro, HFPO-TA hexafluoropropylene oxide trimer acid, Ammonium 2-(perfluoropropoxy)perfluoropropionate, HFPO-TrA hexafluoropropylene oxide trimer acid, ammonium perfluoro(2-methyl-3-oxahexanoic) acid, GenX ammonium perfluoro-2-methyl-3-oxahexanoate, HFPO-TeA hexafluoropropylene oxide tetramer acid, ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate, Propanoic acid, 2,3,3,3-tetrafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)-, sodium salt (1:1), acetone, hexafluoro, perfluoro(2-propoxypropanoate), pgfxowrddhcdte-uhfffaoysa-n, un1956, 428-59-1, Hexafluoropropene oxide, 2,2,3-Trifluoro-3-(trifluoromethyl)oxirane, Hfpo, Hexafluoro-1,2-epoxypropane, Hexafluoropropene epoxide, Hexafluoroepoxypropane, Oxirane, trifluoro(trifluoromethyl)-, Hexafluoropropylene epoxide, Propylene oxide hexafluoride, JPY12AP87N, Propane, 1,2-epoxy-1,1,2,3,3,3-hexafluoro-, Perfluoro-1,2-epoxypropane, Perfluoro-1,2-propenoxide, MFCD00005125, NA1956, SCHEMBL37265, Hexafluoropropylene oxide, 98%, AKOS009157112, FS-3801, CS-0069521, NS00002152, 2,2,3-Trifluoro-3-(trifluoromethyl)oxirane #, Q2693924, Hexafluoropropylene oxide [NA1956] [Nonflammable gas]

Application

Hexafluoropropylene oxide serves as a critical intermediate in the production of perfluoropolyethers (PFPEs) used in high-performance lubricants and vacuum pump oils. It is employed in semiconductor manufacturing for plasma etching and as a precursor to fluorinated surfactants with exceptional thermal and chemical resistance. Researchers also utilize HFPO for surface modification to create ultra-hydrophobic coatings in biomedical and industrial applications.

Safety and Hazards

GHS Hazard Statements

• H280 (74.2%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]
• H315 (62.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (62.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (13.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (75.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (13.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, P410+P403, and P501

Hazard Classes and Categories

• Press. Gas (74.2%)
• Skin Irrit. 2 (62.1%)
• Eye Irrit. 2 (62.1%)
• Acute Tox. 3 (13.6%)
• STOT SE 3 (75.8%)
• STOT RE 2 (13.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.