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Atomfair H-Dab(boc)-OH H-Dab(Boc)-OH C9H18N2O4

Description H-Dab(Boc)-OH ( (2S)-2-amino-4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid ) is a high-purity, Boc-protected amino acid derivative widely used in peptide synthesis and pharmaceutical research. With the molecular formula C9H18N2O4and CAS number 10270-94-7 , this compound serves as a critical building block for introducing the diamino butyric acid (Dab) moiety into peptide chains while protecting the side-chain amine with a tert-butoxycarbonyl (Boc) group. Its chiral purity (>98%) ensures optimal performance in solid-phase peptide synthesis (SPPS) and solution-phase coupling reactions. This white to off-white crystalline powder is rigorously tested via HPLC, NMR, and MS to meet the stringent requirements of medicinal chemistry and bioconjugation applications.…

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Description

Description

H-Dab(Boc)-OH ((2S)-2-amino-4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid) is a high-purity, Boc-protected amino acid derivative widely used in peptide synthesis and pharmaceutical research. With the molecular formula C9H18N2O4 and CAS number 10270-94-7, this compound serves as a critical building block for introducing the diamino butyric acid (Dab) moiety into peptide chains while protecting the side-chain amine with a tert-butoxycarbonyl (Boc) group. Its chiral purity (>98%) ensures optimal performance in solid-phase peptide synthesis (SPPS) and solution-phase coupling reactions. This white to off-white crystalline powder is rigorously tested via HPLC, NMR, and MS to meet the stringent requirements of medicinal chemistry and bioconjugation applications. Store under inert conditions at -20??C for long-term stability.

  • CAS No: 10270-94-7
  • Molecular Formula: C9H18N2O4
  • Molecular Weight: 218.25
  • Exact Mass: 218.12665706
  • Monoisotopic Mass: 218.12665706
  • IUPAC Name: (2S)-2-amino-4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
  • SMILES: CC(C)(C)OC(=O)NCC[C@@H](C(=O)O)N
  • Synonyms: 10270-94-7, H-DAB(BOC)-OH, H-Daba(Boc)-OH, Butanoic acid, 2-amino-4-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)-, (2S)-2-amino-4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic Acid

Application

H-Dab(Boc)-OH is extensively employed in peptide synthesis as a Boc-protected derivative of 2,4-diaminobutyric acid (Dab), enabling controlled incorporation of this non-proteinogenic amino acid into peptide sequences. It is particularly valuable in constructing peptidomimetics, constrained peptides, and linker systems for drug delivery. The Boc group provides orthogonal protection for the side-chain amine during Fmoc-based SPPS, allowing selective deprotection for further modifications. Researchers also utilize this compound in the development of enzyme inhibitors, antibody-drug conjugates (ADCs), and stabilized bioactive peptides.

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