Description

Fluoromethyl 2-pyridyl sulfone (CAS No. 1365765-53-2) is a high-purity sulfone derivative with the molecular formula C₆H₆FNO₂S and IUPAC name 2-(fluoromethylsulfonyl)pyridine. This specialized organic compound features a pyridine ring functionalized with a fluoromethyl sulfone group, making it a valuable building block for synthetic chemistry applications. The product is supplied as a white to off-white crystalline solid with ≥95% purity (HPLC). It is stable under recommended storage conditions (2-8°C in a tightly sealed container under inert atmosphere) but should be protected from moisture and light. This reagent is particularly useful in nucleophilic substitution reactions, cross-coupling chemistry, and as a precursor for pharmaceutical intermediates. Suitable for research and development purposes only, not for drug or household use.

Properties

• CAS Number: 1365765-53-2
• Complexity: 209
• IUPAC Name: 2-(fluoromethylsulfonyl)pyridine
• InChI: InChI=1S/C6H6FNO2S/c7-5-11(9,10)6-3-1-2-4-8-6/h1-4H,5H2
• InChI Key: KCKYDPXAKVBJHE-UHFFFAOYSA-N
• Exact Mass: 175.01032777
• Molecular Formula: C6H6FNO2S
• Molecular Weight: 175.18
• SMILES: C1=CC=NC(=C1)S(=O)(=O)CF
• Topological: 55.4
• Monoisotopic Mass: 175.01032777
• Synonyms: Fluoromethyl 2-pyridyl sulfone, 1365765-53-2, Pyridine, 2-[(fluoromethyl)sulfonyl]-, 2-((fluoromethyl)sulfonyl)pyridine, 2-[(Fluoromethyl)sulfonyl]pyridine, MFCD28100935, 2-FLUOROMETHANESULFONYLPYRIDINE, 2-(fluoromethylsulfonyl)pyridine, Fluoromethyl2-pyridylsulfone, SCHEMBL26694715, QEC76553, AKOS037645782, AS-63464, SY072365, DB-422642, F81443

Application

Fluoromethyl 2-pyridyl sulfone serves as a versatile reagent in medicinal chemistry and materials science. It is commonly employed as an electrophilic fluoromethylation agent in the synthesis of bioactive molecules. The compound finds particular utility in palladium-catalyzed cross-coupling reactions for constructing complex heterocyclic systems. Researchers also utilize this sulfone derivative in the development of PET radiotracers due to its fluorine-containing moiety. Its unique reactivity profile makes it valuable for creating sulfone-containing pharmaceutical intermediates.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (100%)
• STOT SE 3 (100%)

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