Description

Fluoro(iodo)methane (CAS 373-53-5) is a specialized halogenated methane derivative with the molecular formula CH₂FI. This compound is a valuable reagent in synthetic organic chemistry, particularly for introducing fluorine and iodine functional groups into target molecules. Its unique reactivity profile makes it suitable for nucleophilic substitutions, radical reactions, and as a building block for more complex fluorinated and iodinated compounds. Fluoro(iodo)methane is supplied as a high-purity gas or liquid (depending on storage conditions) and should be handled with care due to its potential volatility and reactivity. Researchers utilize this compound in the development of pharmaceuticals, agrochemicals, and advanced materials where selective halogenation is required. Proper storage under inert atmosphere and low temperatures is recommended to maintain stability.

Properties

• CAS Number: 373-53-5
• Complexity: 4.8
• IUPAC Name: fluoro(iodo)methane
• InChI: InChI=1S/CH2FI/c2-1-3/h1H2
• InChI Key: XGVXNTVBGYLJIR-UHFFFAOYSA-N
• Exact Mass: 159.91853
• Molecular Formula: CH2FI
• Molecular Weight: 159.929
• SMILES: C(F)I
• Monoisotopic Mass: 159.91853
• Synonyms: 373-53-5, Fluoro(iodo)methane, Methane, fluoroiodo-, DTXSID00553763, DTXCID30504546, 676-335-7, Fluoroiodomethane, Fluoro-iodo-methane, Fluoromethyl iodide, MFCD12404952, Fluoroiodomethane (ca. 2mol/L in Acetonitrile), iodofluoromethane, fluoromethyliodide, Fluor-jod-methan, fluoro-iodomethane, CH2FI, SCHEMBL19443, SCHEMBL324467, F4DZ382EN9, SCHEMBL2160906, XGVXNTVBGYLJIR-UHFFFAOYSA-N, AT16478, FF77065, WS-00379, F1279, EN300-297917, Fluoroiodomethane (ca. 2 mol/L in Acetonitrile), Q1002152

Application

Fluoro(iodo)methane serves as a versatile reagent in organic synthesis for simultaneous fluorination and iodination reactions. It is employed in pharmaceutical research to create novel fluorinated drug candidates with enhanced metabolic stability. The compound also finds use in materials science for modifying polymer properties through halogen incorporation. Its bifunctional nature allows for selective transformations in complex molecule synthesis.

Safety and Hazards

GHS Hazard Statements

• H225 (50%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H330 (50%): Fatal if inhaled [Danger Acute toxicity, inhalation]
• H331 (50%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (50%)
• Acute Tox. 3 (100%)
• Acute Tox. 3 (100%)
• Skin Irrit. 2 (50%)
• Eye Irrit. 2A (50%)
• Acute Tox. 2 (50%)
• Acute Tox. 3 (50%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.