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Atomfair Ethyl difluoro(iodo)acetate C4H5F2IO2

Description Ethyl difluoro(iodo)acetate (CAS No. 7648-30-8) is a highly specialized fluorinated organic compound with the molecular formula C4H5F2IO2. Also known as ethyl 2,2-difluoro-2-iodoacetate , this reagent is widely utilized in synthetic organic chemistry and pharmaceutical research due to its unique reactivity as an electrophilic difluoromethylation agent. The compound features an iodine substituent adjacent to a difluoroacetate ester group, making it a versatile building block for the introduction of difluoromethyl motifs into target molecules. Its high purity grade ensures optimal performance in demanding applications such as nucleophilic substitutions, cross-coupling reactions, and radical-mediated transformations. Packaged under inert conditions to maintain stability, this…

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Description

Description

Ethyl difluoro(iodo)acetate (CAS No. 7648-30-8) is a highly specialized fluorinated organic compound with the molecular formula C4H5F2IO2. Also known as ethyl 2,2-difluoro-2-iodoacetate, this reagent is widely utilized in synthetic organic chemistry and pharmaceutical research due to its unique reactivity as an electrophilic difluoromethylation agent. The compound features an iodine substituent adjacent to a difluoroacetate ester group, making it a versatile building block for the introduction of difluoromethyl motifs into target molecules. Its high purity grade ensures optimal performance in demanding applications such as nucleophilic substitutions, cross-coupling reactions, and radical-mediated transformations. Packaged under inert conditions to maintain stability, this product is ideal for researchers seeking reliable and efficient fluorination strategies.

  • CAS No: 7648-30-8
  • Molecular Formula: C4H5F2IO2
  • Molecular Weight: 249.98
  • Exact Mass: 249.93023
  • Monoisotopic Mass: 249.93023
  • IUPAC Name: ethyl 2,2-difluoro-2-iodoacetate
  • SMILES: CCOC(=O)C(F)(F)I
  • Synonyms: ETHYL DIFLUORO(IODO)ACETATE, 671-653-2, Ethyl iododifluoroacetate, 7648-30-8, ethyl 2,2-difluoro-2-iodoacetate

Application

Ethyl difluoro(iodo)acetate serves as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals, enabling the incorporation of difluoromethyl groups into complex molecular architectures. It is particularly valuable in palladium-catalyzed cross-coupling reactions and nucleophilic substitutions for constructing C-CF2 bonds. Researchers also employ this reagent in radical chemistry to generate difluoromethyl radicals under mild conditions. Its applications extend to materials science, where it aids in the development of fluorinated polymers with enhanced properties.

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