Description

Ethyl Acetate (CAS 141-78-6) is a high-purity, versatile ester with the molecular formula C₄H₈O₂, widely used in laboratory and industrial applications. Known for its fast evaporation rate and mild, fruity odor, it serves as an excellent solvent for resins, adhesives, coatings, and pharmaceuticals. This reagent-grade ethyl acetate (≥99.5% purity) is rigorously tested for consistency, ensuring optimal performance in chromatography (HPLC, GC), organic synthesis, and extraction processes. Packaged in amber glass bottles or chemical-resistant containers to maintain stability, it is ideal for sensitive applications requiring low water content and minimal impurities. Suitable for use in research, diagnostics, and manufacturing under controlled conditions.

Properties

• CAS Number: 141-78-6
• Complexity: 49.5
• IUPAC Name: ethyl acetate
• InChI: InChI=1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3
• InChI Key: XEKOWRVHYACXOJ-UHFFFAOYSA-N
• LogP: log Kow = 0.73
• Exact Mass: 88.052429494
• Molecular Formula: C4H8O2
• Molecular Weight: 88.11
• SMILES: CCOC(=O)C
• Topological: 26.3
• Monoisotopic Mass: 88.052429494
• Physical Description: Ethyl acetate appears as a clear colorless liquid with a fruity odor. Flash point 24 °F. Less dense than water. Vapors heavier than air.
• Color/Form: Clear, volatile
• Odor: CHARACTERISTIC ETHER-LIKE ODOR REMINISCENT OF PINEAPPLE.
• Taste: Pleasant taste when diluted
• Boiling Point: 171 °F at 760 mmHg
• Melting Point: -118.5 °F
• Flash Point: 24 °F
• Solubility: 50 to 100 mg/mL at 70 °F
• Density: 0.902 at 68 °F – Less dense than water; will float
• Vapor Density: 3.04 – Heavier than air; will sink
• Vapor Pressure: 73 mmHg at 68 °F ; 100 mmHg at 81 °F
• Henry’s Law Constant: Henry’s Law constant = 1.34X10-4 atm-cu m/mole at 25 °C
• Stability/Shelf Life: Slowly decomp by moisture.
• Autoignition Temperature: 800 °F
• Viscosity: 0.423 mPa.s at 25 °C
• Heat of Combustion: 2238.1 kJ/mol
• Heat of Vaporization: 35.60 kJ/mol at 25 °C
• Surface Tension: 24 DYNES/CM AT 20 °C
• Ionization Potential: 10.01 eV
• Odor Threshold: Odor Threshold Low: 6.4 [ppm]
• Refractive Index: Index of refraction = 1.3723 at 20 °C/D
• Synonyms: ETHYL ACETATE, 141-78-6, Ethyl ethanoate, Acetic acid ethyl ester, Acetoxyethane, Vinegar naphtha, Acetic ether, Ethyl acetic ester, Acetic acid, ethyl ester, Ethylacetate, Acetidin, Essigester, EtOAc, Aethylacetat, Ethylacetat, 1-acetoxyethane, AcOEt, RCRA waste number U112, Ethylacetaat, Octan etylu, FEMA No. 2414, Etile (acetato di), Ethylazetat, Caswell No. 429, Ethyle (acetate d’), Acetate d’ethyle, Acetato de etilo, Ethyl acetate (natural), Ethylester kyseliny octove, CHEBI:27750, Essigsaeureethylester, acetic-acid-ethylester, HSDB 83, NSC 70930, Ethylether, CCRIS 6036, acet-ethylester, acet-eth-ester, EINECS 205-500-4, NSC-70930, CH3-CO-O-CH3, EPA Pesticide Chemical Code 044003, UNII-76845O8NMZ, DTXSID1022001, AI3-00404, 76845O8NMZ, DTXCID602001, EC 205-500-4, NSC70930, ETHYL ACETATE (II), ETHYL ACETATE [II], ETHYL ACETATE (MART.), ETHYL ACETATE [MART.], ETHYL ACETATE (EP MONOGRAPH), ETHYL ACETATE [EP MONOGRAPH], Caswell No 429, 205-500-4, ethyl acetate (acgih:osha), Acetic ester, Ethyl ester of acetic acid, MFCD00009171, Ethyl acetate [NF], ETHYL ACETATE (1-13C), Ethyl acetate (NF), NCGC00091766-01, E1504, Ethyl acetate, ACS reagent, Ethyl acetate; Ethyl ethanoate, Essigester [German], Ethylacetaat [Dutch], Aethylacetat [German], Octan etylu [Polish], ethyl-acetate, acetic acid ethyl, Acetate d’ethyle [French], Acetato de etilo [Spanish], Ethyl acetate, ACS reagent, >=99.5%, CAS-141-78-6, Etile (acetato di) [Italian], Ethyle (acetate d’) [French], Ethylester kyseliny octove [Czech], UN1173, CH3COOC2H5, RCRA waste no. U112, ethylaceate, ethylactate, ethylacteate, Etylacetate, ehtyl acetate, ethanol acetate, ethly acetate, ethyl acteate, ethyl_acetate, ehyl acetate, ethl acetate, ethy acetate, ethyl aceate, ethyl actate, etyl acetate, Acetyl ester, 1-ethyl acetate, 2~ethyl acetate, acetic ethyl ester, Etile(acetato di), Et-OAc, Ethyle(acetate d’), acetic acid ethylester, Ethyl Acetate, HPLC, CH3CO2Et, Ethyl acetate HPLC grade, Ethyl acetate, for HPLC, Ethyl acetate, 99.9%, Ethyl acetate, ACS grade, SCHEMBL155, CH3CO2CH2CH3, Epitope ID:116868, ETHYL ACETATE [MI], Ethyl acetate, HPLC Grade, SCHEMBL5151, CH3CO2C2H5, ETHYL ACETATE [FCC], SCHEMBL22552, SCHEMBL22553, ETHYL ACETATE [FHFI], ETHYL ACETATE [HSDB], Ethyl acetate, >=99.5%, WLN: 2OV1, CHEMBL14152, SCHEMBL845172, ACETIC ACID,ETHYL ESTER, Ethyl acetate, AR, >=99%, Ethyl acetate, LR, >=99%, SCHEMBL5179908, SCHEMBL8776921, SCHEMBL9464138, ETHYL ACETATE [USP-RS], ETHYL ACETATE [WHO-DD], Ethyl acetate, analytical standard, Ethyl acetate, Environmental Grade, Ethyl acetate, anhydrous, 99.8%, AAA14178, Ethyl acetate, 99.9% low benzene, Tox21_111166, Tox21_202512, BDBM50128823, c0036, MSK6707-100M, STL282717, Ethyl acetate, >=99%, FCC, FG, Ethyl acetate, HPLC grade, 99.8%, AKOS000121947, Ethyl acetate, Spectrophotometric Grade, UN 1173, Ethyl acetate, for HPLC, >=99.5%, Ethyl acetate, for HPLC, >=99.7%, Ethyl acetate, for HPLC, >=99.8%, NCGC00260061-01, Ethyl acetate, biotech. grade, >=99.8%, Ethyl acetate, ReagentPlus(R), >=99.8%, Ethyl acetate, tested according to Ph.Eur., A0030, Ethyl acetate 100 microg/mL in Acetonitrile, Ethyl acetate, natural, >=99%, FCC, FG, Ethyl acetate, SAJ first grade, >=99.0%, NS00004207, Q0040, EN300-31487, Ethyl acetate [UN1173] [Flammable liquid], Ethyl acetate Solution in Methanol, 100ug/mL, Ethyl acetate, for HPLC, >=99.8% (GC), Ethyl acetate, JIS special grade, >=99.5%, C00849, D02319, A807811, Q407153, Ethyl acetate, Laboratory Reagent, >=99.0% (GC), Ethyl acetate, UV-IR min. 99.8%, isocratic grade, F0001-0489, InChI=1/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H, Ethyl acetate, puriss. p.a., ACS reagent, >=99.5% (GC), Ethyl acetate, United States Pharmacopeia (USP) Reference Standard, Ethylacetate, pure, meets the analytical specifications of Ph. Eur., Ethyl Acetate, Pharmaceutical Secondary Standard; Certified Reference Material, Ethyl acetate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5% (GC), Ethyl acetate, puriss. p.a., free of higher boiling impurities, >=99.9% (GC), Ethyl acetate, puriss., meets analytical specification of Ph. Eur., BP, NF, >=99.5% (GC)

Application

Ethyl acetate is a key solvent in pharmaceutical manufacturing, particularly for tablet coatings and active ingredient purification. It is widely employed in food and fragrance industries as a flavoring agent due to its low toxicity and pleasant aroma. In analytical chemistry, it serves as a mobile phase in chromatography and an extraction medium for natural products. Its fast evaporation rate makes it ideal for nail polish removers and cleaning applications in electronics.

Safety and Hazards

GHS Hazard Statements

• H225: Highly Flammable liquid and vapor [Danger Flammable liquids]
• H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flammable liquids – Category 2
• Acute toxicity – Category 4
• Serious eye damage/eye irritation – Category 2B
• Specific target organ toxicity – Single exposure – Category 3

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.