Atomfair Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate C8H9ClN2O2S CAS 5909-24-0

Description

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate (CAS No. 5909-24-0) is a high-purity pyrimidine derivative with the molecular formula C₈H₉ClN₂O₂S. This compound is a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. Its IUPAC name, ethyl 4-chloro-2-methylsulfanylpyrimidine-5-carboxylate, reflects its structural features, including a chloro-substituted pyrimidine ring, a methylthio group at the 2-position, and an ethoxycarbonyl moiety at the 5-position.

Our product is rigorously tested for purity and consistency, ensuring optimal performance in synthetic applications. It is supplied as a crystalline solid with excellent stability under recommended storage conditions. Researchers and chemists will appreciate its reliability for use in nucleophilic substitution reactions, cross-coupling reactions, and as a building block for heterocyclic compounds.

Synonyms include: 2-methylthio-4-chloro-5-ethoxycarbonylpyrimidine, 4-Chloro-5-carbethoxy-2-methylthiopyrimidine, and 3EZY6B6CLY.

Properties

• CAS Number: 5909-24-0
• Complexity: 206
• IUPAC Name: ethyl 4-chloro-2-methylsulfanyl-pyrimidine-5-carboxylate
• InChI: InChI=1S/C8H9ClN2O2S/c1-3-13-7(12)5-4-10-8(14-2)11-6(5)9/h4H,3H2,1-2H3
• InChI Key: SNNHLSHDDGJVDM-UHFFFAOYSA-N
• Exact Mass: 232.0073264
• Molecular Formula: C8H9ClN2O2S
• Molecular Weight: 232.69
• SMILES: CCOC(=O)C1=CN=C(N=C1Cl)SC
• Topological: 77.4
• Monoisotopic Mass: 232.0073264
• Synonyms: 5909-24-0, Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate, 2-methylthio-4-chloro-5-ethoxycarbonylpyrimidine, 4-Chloro-5-carbethoxy-2-methylthiopyrimidine, 3EZY6B6CLY, 5-Pyrimidinecarboxylic acid, 4-chloro-2-(methylthio)-, ethyl ester, 4-Chloro-2-methylsulfanylpyrimidine-5-carboxylic acid ethyl ester, EINECS 227-619-0, NSC-123534, Ethyl 4-chloro-2-(methylthio)-5-pyrimidinecarboxylate, DTXSID20207832, 4-chloro-5-ethoxycarbonyl-2-methylthiopyrimidine, NSC 123534, ethyl 4-chloro-2-methylsulfanyl-5-pyrimidinecarboxylate, 4-CHLORO-2-METHYLTHIO-5-CARBETHOXYPYRIMIDINE, 4-chloro-2-(methylthio)-5-pyrimidinecarboxylic acid ethyl ester, 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester, 4-CHLORO-2-METHANETHIOPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER, DTXCID70130323, 227-619-0, snnhlshddgjvdm-uhfffaoysa-n, ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate, Ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate, 4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester, ethyl 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylate, ethyl 4-chloro-2-methylsulfanylpyrimidine-5-carboxylate, MFCD00006085, ethyl 4-chloro-2-methylthio-5-pyrimidine carboxylate, 4-Chloro-2-(methylthio)pyrimidine-5-carboxylic Acid Ethyl Ester, NSC123534, UNII-3EZY6B6CLY, SCHEMBL188686, ethyl 4-chloro-2-(methylthio)pyrimidine -5-carboxylate, ethyl 4-chloro-2-methylsulfanyl-pyrimidine-5-carboxylate, BCP00790, CS-M1026, GEO-01330, SBB059077, STK727415, AKOS003106956, 6N-537S, AC-2398, FE15899, PB21605, SB10541, AC-26681, HY-76558, SY013568, DB-010273, E0841, NS00034081, ST51006895, EN300-60275, 5-ethoxycarbonyl-4-chloro-2-methylthiopyrimidine, 4-chloro-5-ethoxycarbonyl-2-methylthio-pyrimidine, ethyl-4-chloro-2-methylthio-5-pyrimidinecarboxylate, ethyl 4-chloro-2(methylthio)pyrimidine-5-carboxylate, ethyl 4-chloro-2-(methylthio)pyrimidin-5-carboxylate, ethyl 4-chloro-2-methylthio-5-pyrimidine-carboxylate, ethyl-4-chloro-2-methylthio-5-pyrimidine carboxylate, ethyl-4-chloro-2-methylthio-5-pyrimidine-carboxylate, ethyl 4-chloro-2-(methylthio)-pyrimidine-5-carboxylate, ethyl 4-chloro-2-(methylthio)pyrimidine-5-carb oxylate, F3284-7955, Z935262556, 4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl ester, Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate, 98%, 2-methylthio-4-chloropyrimidine-5-carboxylic acid ethyl ester, 4-chloro-2-methylsulfanyl-5-pyrimidinecarboxylate ethyl ester, 4-chloro-2-methylthio-5-pyrimidine carboxylic acid ethyl ester, Ethyl 4-chloro-2-(methylsulfanyl)-5-pyrimidinecarboxylate #, 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester, ETHYL 4-CHLORO-2-(METHYLMERCAPTO)PYRIMIDINE-5-CARBOXYLATE

Application

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate is widely used as a key intermediate in the synthesis of pyrimidine-based pharmaceuticals, including antiviral and anticancer agents. It serves as a precursor for the preparation of substituted pyrimidines through nucleophilic aromatic substitution reactions. Additionally, this compound is utilized in agrochemical research for developing novel herbicides and pesticides. Its reactivity makes it valuable for constructing complex heterocyclic frameworks in medicinal chemistry.

Safety and Hazards

GHS Hazard Statements

• H315 (98.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (18.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (11.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (86.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (98.3%)
• Skin Sens. 1 (18.3%)
• Eye Dam. 1 (11.7%)
• Eye Irrit. 2 (86.7%)
• STOT SE 3 (95%)

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