Description

Description

Ethyl 3,3,3-Trifluoropropionate (CAS No. 352-23-8) is a high-purity fluorinated ester with the molecular formula C₅H₇F₃O₂, widely utilized in advanced organic synthesis and pharmaceutical research. This compound, also known by its IUPAC name ethyl 3,3,3-trifluoropropanoate, features a trifluoromethyl group that enhances its reactivity and stability, making it a valuable building block for fluorinated molecules. With a clear liquid appearance and a molecular weight of 156.10 g/mol, it is characterized by its excellent solubility in common organic solvents such as dichloromethane, ethanol, and ether. Ideal for nucleophilic substitution reactions, cross-coupling, and as a precursor for agrochemicals or bioactive compounds, this reagent is rigorously tested for quality (purity ??98% by GC) and supplied in secure, chemically resistant packaging to ensure optimal shelf life and performance.

Application

Ethyl 3,3,3-Trifluoropropionate serves as a versatile intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and specialty materials. Its trifluoromethyl group is pivotal in modulating the lipophilicity and metabolic stability of target molecules, making it valuable in drug discovery. The compound is also employed in the preparation of liquid crystals and coatings due to its unique electronic properties. Researchers leverage its reactivity in palladium-catalyzed cross-coupling reactions to introduce fluorinated motifs into complex organic frameworks.

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