Description

Ethyl 2-nitrophenylacetate (CAS No. 31912-02-4) is a high-purity organic ester compound with the molecular formula C₁₀H₁₁NO₄. This yellow to pale brown liquid is widely utilized in synthetic organic chemistry, particularly as a versatile intermediate in the preparation of pharmaceuticals, agrochemicals, and fine chemicals. Its IUPAC name, ethyl 2-(2-nitrophenyl)acetate, reflects its structural composition, featuring a nitrophenyl group adjacent to an acetate ester functionality. With a molecular weight of 209.20 g/mol, this compound exhibits moderate solubility in common organic solvents such as ethanol, acetone, and dichloromethane, while being sparingly soluble in water. Researchers value Ethyl 2-nitrophenylacetate for its reactivity in nucleophilic substitution and reduction reactions, making it valuable for constructing complex molecular architectures. Our product is rigorously tested to ensure ≥95% purity (GC) and is supplied in amber glass bottles under inert atmosphere to maintain stability.

Properties

• CAS Number: 31912-02-4
• Complexity: 236
• IUPAC Name: ethyl 2-(2-nitrophenyl)acetate
• InChI: InChI=1S/C10H11NO4/c1-2-15-10(12)7-8-5-3-4-6-9(8)11(13)14/h3-6H,2,7H2,1H3
• InChI Key: CJHXMQCYEILGFT-UHFFFAOYSA-N
• Exact Mass: 209.06880783
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.20
• SMILES: CCOC(=O)CC1=CC=CC=C1[N+](=O)[O-]
• Topological: 72.1
• Monoisotopic Mass: 209.06880783
• Synonyms: 31912-02-4, Ethyl 2-nitrophenylacetate, DTXSID60344311, DTXCID30295386, ethyl 2-(2-nitrophenyl)acetate, Ethyl (2-nitrophenyl)acetate, 2-Nitrophenyl acetic acid ethyl ester, (2-Nitro-phenyl)-acetic acid ethyl ester, Benzeneacetic acid, 2-nitro-, ethyl ester, MFCD00092226, 2-Nitrophenylacetic acid ethyl ester, Maybridge1_006245, Oprea1_434832, ethyl (2-nitrophenyl)-acetate, ethyl2-(2-nitrophenyl)acetate, SCHEMBL3796044, Ethyl benzeneacetate, 2-nitro-, Ethyl (2-nitrophenyl)acetate #, SCHEMBL14592343, SCHEMBL16466488, HMS559D19, SBB094174, AKOS015888293, AC-4372, PS-4729, SB36559, SY005240, DB-068549, CS-0042739, AE-562/43460576

Application

Ethyl 2-nitrophenylacetate serves as a key synthetic intermediate in medicinal chemistry for the preparation of indole and quinoline derivatives. The compound’s nitro group facilitates subsequent reduction to amines or conversion to other functional groups, enabling diverse pharmaceutical applications. In material science, it acts as a precursor for photosensitive compounds and specialty polymers. The ester functionality allows for further transformations via hydrolysis or transesterification reactions, expanding its utility in custom synthesis.

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