Description

Ethanol, 2-[(4-methylphenyl)sulfonyl]-, also known as 2-Tosylethanol, is a high-purity sulfonated ethanol derivative widely used in organic synthesis and pharmaceutical research. With the molecular formula C₉H₁₂O₃S and CAS number 22381-54-0, this compound serves as a versatile building block for the preparation of sulfonate esters and other functionalized intermediates. Its unique structure, featuring a toluenesulfonyl group attached to an ethanol moiety, makes it ideal for nucleophilic substitution reactions, protecting group strategies, and cross-coupling applications. Our product is rigorously tested for purity and consistency, ensuring reliable performance in demanding laboratory and industrial processes. Packaged under controlled conditions to maintain stability, it is an essential reagent for researchers in medicinal chemistry, materials science, and fine chemical synthesis.

Properties

• CAS Number: 22381-54-0
• Complexity: 232
• IUPAC Name: 2-(p-tolylsulfonyl)ethanol
• InChI: InChI=1S/C9H12O3S/c1-8-2-4-9(5-3-8)13(11,12)7-6-10/h2-5,10H,6-7H2,1H3
• InChI Key: QJFIXBNLKARINT-UHFFFAOYSA-N
• Exact Mass: 200.05071541
• Molecular Formula: C9H12O3S
• Molecular Weight: 200.26
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)CCO
• Topological: 62.8
• Monoisotopic Mass: 200.05071541
• Synonyms: Ethanol, 2-(p-tolylsulfonyl)-, 2-[(4-Methylphenyl)sulfonyl]ethanol, Ethanol, 2-[(4-methylphenyl)sulfonyl]-, 2-(4-Methylphenylsulfonyl)ethanol, NSC 70003, Ethanol, 2-((4-methylphenyl)sulfonyl)-, AI3-07259, DTXSID1066786, 2-((4-Methylphenyl)sulfonyl)ethanol, DTXCID6036675, Ethanol, 2-(p-tolylsulfonyl)-(8CI), 625-269-7, 2-Tosylethanol, 22381-54-0, 2-(p-Toluenesulfonyl)ethanol, 2-(p-Tolylsulfonyl)ethanol, 2-(4-methylphenyl)sulfonylethanol, MFCD00041757, 2-(Toluene-4-sulfonyl)ethanol, NSC70003, 2-Tosylethan-1-ol, 2-p-Toluenesulfonylethanol, 2-(p-tolylsulfonyl) ethanol, SCHEMBL505791, 2-(p-toluenesulfonyl)-ethanol, SCHEMBL8742947, 2-(p-Tolylsulfonyl)ethanol, 97%, NSC-70003, p-Methylphenyl 2-hydroxyethyl sulfone, AKOS003365870, 2-(4-methylbenzenesulfonyl)ethan-1-ol, FS-1158, 2-[(4-Methylphenyl)sulfonyl]ethanol #, 1-[(4-methylphenyl)sulfonyl]ethan-2-ol, 272440-04-7, SY048814, DB-045892, CS-0042623, ST50405755, T1620

2-[(4-Methylphenyl)sulfonyl]ethanol is commonly employed as a key intermediate in the synthesis of sulfonate esters, which are pivotal in polymer chemistry and drug development. It acts as a protective group for alcohols in multistep organic transformations, enabling selective reactivity. Researchers also utilize it in the preparation of chiral auxiliaries and as a precursor for surfactants or phase-transfer catalysts. Its stability and solubility in common organic solvents make it suitable for diverse reaction conditions.

Safety and Hazards

GHS Hazard Statements

• H302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral]

Precautionary Statements

• P264, P270, P301+P317, P330, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.5%)

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