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Atomfair Ethanesulfonyl fluoride C2H5FO2S CAS 754-03-0

Ethanesulfonyl fluoride (CAS No. 754-03-0) is a highly reactive organosulfur compound with the molecular formula C2H5FO2S . This colorless to pale yellow liquid is widely utilized in organic synthesis and pharmaceutical research due to its sulfonyl fluoride functional group, which serves as a versatile electrophile in chemical transformations. With a molecular weight of 112.12 g/mol, it exhibits excellent reactivity in nucleophilic substitution reactions, making it a valuable building block for sulfonamide and sulfonate derivatives. Ethanesulfonyl fluoride is stored under inert conditions to prevent hydrolysis and is typically handled in a fume hood due to its potential lachrymatory effects. Suitable for…

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Description

Ethanesulfonyl fluoride (CAS No. 754-03-0) is a highly reactive organosulfur compound with the molecular formula C2H5FO2S. This colorless to pale yellow liquid is widely utilized in organic synthesis and pharmaceutical research due to its sulfonyl fluoride functional group, which serves as a versatile electrophile in chemical transformations. With a molecular weight of 112.12 g/mol, it exhibits excellent reactivity in nucleophilic substitution reactions, making it a valuable building block for sulfonamide and sulfonate derivatives. Ethanesulfonyl fluoride is stored under inert conditions to prevent hydrolysis and is typically handled in a fume hood due to its potential lachrymatory effects. Suitable for use in peptide modification, enzyme inhibition studies, and material science applications, this compound is available in high-purity grades (≥95%) with detailed analytical certifications (GC/MS, NMR).

Properties

  • CAS Number: 754-03-0
  • Complexity: 108
  • IUPAC Name: ethanesulfonyl fluoride
  • InChI: InChI=1S/C2H5FO2S/c1-2-6(3,4)5/h2H2,1H3
  • InChI Key: OIBMEBLCOQCFIT-UHFFFAOYSA-N
  • Exact Mass: 111.99942873
  • Molecular Formula: C2H5FO2S
  • Molecular Weight: 112.13
  • SMILES: CCS(=O)(=O)F
  • Topological: 42.5
  • Monoisotopic Mass: 111.99942873
  • Synonyms: Ethanesulfonyl fluoride, 754-03-0, Ethane sulfonyl fluoride, 809-780-4, oibmeblcoqcfit-uhfffaoysa-n, Ethanesulfonylfluoride, C2H5FO2S, Ethanesulfonyl fluoride, 95%, SCHEMBL737387, SCHEMBL1726681, SCHEMBL1726683, DTXSID201348908, AKOS037652456, AT26952, ES-2121, CS-0250998, EN300-53132

Application

Ethanesulfonyl fluoride is primarily employed as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals and agrochemicals. Its reactive sulfonyl fluoride group enables selective modification of proteins and peptides, making it useful in bioconjugation and proteomics research. Additionally, it serves as a precursor for sulfonate esters in polymer chemistry and as a fluorinating agent in specialty chemical production.

Safety and Hazards

GHS Hazard Statements

  • H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
  • H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

  • P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

  • Flam. Liq. 3 (100%)
  • Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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