Description

1-Fluoro-2-iodoethane (CAS 762-51-6) is a highly specialized halogenated organic compound with the molecular formula C₂H₄FI. This clear to pale yellow liquid is a valuable reagent in synthetic organic chemistry, particularly for introducing fluoroalkyl and iodoalkyl groups into target molecules. With a molecular weight of 189.95 g/mol, it offers precise reactivity for nucleophilic substitution and elimination reactions. The compound is characterized by its unique combination of fluorine and iodine substituents on a short ethane backbone, making it useful for constructing more complex fluorinated intermediates. Proper storage under inert atmosphere and refrigeration is recommended to maintain stability. Purity levels typically exceed 95%, with GC/MS analysis available upon request. This chemical is packaged in amber glass bottles with secure closures to prevent degradation.

Properties

• CAS Number: 762-51-6
• Complexity: 10
• IUPAC Name: 1-fluoro-2-iodo-ethane
• InChI: InChI=1S/C2H4FI/c3-1-2-4/h1-2H2
• InChI Key: LVYJIIRJQDEGBR-UHFFFAOYSA-N
• Exact Mass: 173.93418
• Molecular Formula: C2H4FI
• Molecular Weight: 173.96
• SMILES: C(CI)F
• Monoisotopic Mass: 173.93418
• Synonyms: 762-51-6, Ethane, 1-fluoro-2-iodo-, 2-Fluoroethyl iodide, 1-Fluor-2-jodethan, 1-Fluor-2-jodethan [Czech], BRN 1730862, DTXSID80227056, 4-01-00-00165 (Beilstein Handbook Reference), DTXCID80149547, 1-Fluoro-2-iodoethane, 1-fluoro-2-iodo-ethane, 2-fluoro-1-iodoethane, 1-iodo-2-fluoroethane, MFCD00748131, 1-Fluoro-2-iodoethane, contains up to 1% copper powder as stabilizer, C2H4FI, 2-iodo-1-fluoroethane, 1-fluoro-2-ethyl iodide, SCHEMBL126270, SCHEMBL9251310, SCHEMBL28132840, LVYJIIRJQDEGBR-UHFFFAOYSA-N, SBB088831, AKOS006227793, FF87523, AS-31130, SY024380, 1-Fluoro-2-iodoethane, stabilized over Cu, DB-005720, F1190, EN300-316786, 1-Fluoro-2-iodoethane (stabilized with Copper chip), 2-Fluoro-1-iodoethane, 2-Iodoethyl fluoride, 2-Fluoroethyl iodide

Application

1-Fluoro-2-iodoethane serves as a versatile building block in pharmaceutical and materials science research. It is particularly valuable for synthesizing fluorinated analogs of biologically active compounds in medicinal chemistry. The compound finds use in nucleophilic substitution reactions to create fluoroethylamine derivatives. Researchers also employ it in the preparation of fluorinated polymers with unique electronic properties. Its dual functionality allows for sequential transformations in multi-step synthetic routes.

Safety and Hazards

GHS Hazard Statements

• H225 (50%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H301+H311+H331 (16.7%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H301 (50%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (16.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (50%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (83.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (83.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (50%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (50%)
• Acute Tox. 3 (50%)
• Acute Tox. 4 (16.7%)
• Acute Tox. 3 (50%)
• Skin Irrit. 2 (83.3%)
• Eye Irrit. 2 (83.3%)
• Acute Tox. 3 (50%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.